Using brain tissues from non-human primates (NHPs), the ideal model to mimic human hippocampal aging, scientists from the Institute of Stem Cell and Regeneration，CAS and Xuanwu Hospital Capital Medical University have established the first single-nucleus transcriptomic landscape of primate hippocampal aging, revealed the molecular mechanism of its functional deterioration with age...

In a recent study published in PNAS, Prof. Feng Liu 's group established the first developmental single-cell transcriptomic atlases of HSPC expansion in zebrafish and provides an essential resource for understanding regulatory mechanisms of HSPC expansion and differentiation in the niche.

The research group led by Prof. Yang-Ling Wang at the Institute of Stem Cell and Regeneration, Chinese Academy of Sciences (CAS), in collaboration with Drs. Chu Wang and Xing Chen from Peking University, has now made a major breakthrough about the regulation of trophoblast differentiation by post-translational protein modification through applying the quantitative O-GlcNAc proteomics in human trophoblasts. This study was published in Cell Chemical Biology on Feb. 23, 2021.

Recently, the researchers from the Institute of Stem Cell and Regeneration,CAS, Peking University, and Beijing Institute of Genomics, CAS have identified new human senescence-promoting genes by using a genome-wide CRISPR/Cas9 screening system and provide a new therapeutic approach for treating aging and aging-related pathologies. The study entitled “A genome-wide CRISPR-base screen identifies KAT7 as a driver of cellular senescence” was published online in Science Translational Medicine.

The research group led by Prof. Yang-Ling Wang at the Institute of Stem Cell and Regeneration,CAS, in collaboration with Dr. Yoel Sadovsky from University of Pittsburgh and Dr. Bin Cao from Xiamen University, have now revealed a unique strategy of STB to adapt to nutrient deprivation and thus support fetal survival. Their study was published in PNAS on Jan. 6, 2021.