现任领导

王红梅

[研究员]

生殖生理研究组

联系方式 wanghm@ioz.ac.cn +86-10-64807187 http://rpb.ioz.cas.cn/yjz/wanghongmei/

教育经历

  • 1999.09~2002.06 中国科学院动物研究所生理学博士

  • 1995.09~1998.07 北京师范大学生物系细胞生物学硕士

  • 1991.09~1995.07 北京师范大学生物系生物学学士

工作经历

  • 2020.01~ 干细胞与再生医学创新研究院副院长

  • 2017.05~ 干细胞与生殖生物学国家重点实验室主任

  • 2006.09~ 干细胞与生殖生物学国家重点实验室研究员、博士生导师、生殖生理研究组组长

  • 2013.01~2020.09 干细胞与生殖生物学国家重点实验室党总支书记

  • 2003.12~2005.12 加拿大渥太华健康研究所(OHRI)博士后

研究方向

本组致力于女性生殖与疾病的研究。主要研究方向为细胞命运决定、胎盘发育与生理和病理的妊娠结局。

代表性发表论文

  1. Yan R#, Gu C#*, You D, Huang Z, Qian J, Yang Q, Cheng X, Zhang L##, Wang H##, Wang P*, Guo F*. Decoding dynamic epigenetic landscapes in human oocytes using single-cell multi-omics sequencing. Cell Stem Cell. S1934-5909(21)00169-7. Epub ahead of print.(##Senior author)

  2. Lim HYG, Alvarez YD, Gasnier M, Wang Y, Tetlak P, Bissiere S, Wang H, Biro M, Plachta N*. Keratins are asymmetrically inherited fate determinants in the mammalian embryo. Nature. 2020, 585(7825), 404-409.

  3. Xiao Z#, Yan L#, Liang X*, Wang H*. Progress in deciphering trophoblast cell differentiation during human placentation. Current Opinion in Cell Biology. 2020, 18(67), 86-91. (invited review)

  4. Jiang X*, Wang H*. Macrophage subsets at the maternal-fetal interface. Cell Mol Immunol. 2020;17(8):889-891.

  5. Ma H#, Zhai J#, Wan H#, Jiang X, Wang X, Wang L, Xiang Y, He X, Zhao ZA, Zhao B, Zheng P*, Li L*, Wang H*. In vitro culture of cynomolgus monkey embryos beyond early gastrulation. Science.2019, 366(6467).

  6. Liu YW#, Fan XY#, Wang R#, Lu XY#, Dang YL, Wang HY, Lin HY, Zhu C, Ge H, Cross JC*, Wang H* Single-cell RNA-seq reveals the diversity of trophoblast subtypes and patterns of differentiation in the human placenta. Cell Reseach, 2018, 28(8):819-832.

  7. Jiang X, Du MR, Li M, Wang H*. Three macrophage subsets are identified in the uterus during early human pregnancy. Cellular & Molecular Immunology (CMI).2018, 15(12), 1027-1037.

  8. Chang WL#, Liu YW#, Dang YL#, Jiang XX, Xu HL, Huang X, Wang YL, Wang H, Zhu C, Xue LQ, Lin HY, Meng WX*, Wang H*. Plac8, a new marker for human interstitial extravillous trophoblast cells, promotes their invasion and migration. Development, 2018,145(2).

  9. Lu XY#, Wang R#, Zhu C, Wang H, Lin HY, Gu Y, Cross JC*, Wang H*. Fine-Tuned and Cell-Cycle-Restricted Expression of Fusogenic Protein Syncytin-2 Maintains Functional Placental Syncytia. Cell Reports. 2017, 21(5), 1150-1159.

  10. Hai T#, Cao C#, Shang H#, Guo W#, Mu Y#, Yang S, Zhang Y, Zheng Q, Zhang T, Wang X, Liu Y, Kong Q, Li K, Wang D, Qi M, Hong Q, Zhang R, Wang X, Jia Q, Wang X, Qin G, Li Y, Luo A, Jin W, Yao J, Huang J, Zhang H, Li M, Xie X, Zheng X, Guo K, Wang Q, Zhang S, Li L, Xie F, Zhang Y, Weng X, Yin Z, Hu K, Cong Y, Zheng P, Zou H, Xin L, Xia J, Ruan J, Li H, Zhao W, Yuan J, Liu Z, Gu W, Li M, Wang Y, Wang H*, Yang S*, Liu Z*, Wei H*, Zhao J*, Zhou Q*, Meng A*. Pilot study of large-scale production of mutant pigs by ENU mutagenesis. Elife. 2017, (6), e26248.

  11. Zhang Y#, Wang Q#, Wang H*, Duan EK*. Uterine Fluid in Pregnancy: A Biological and Clinical Outlook. Trends in Molecular Medicine. 2017, 23(7), 604–614.

  12. Aguilar PS#, Baylies MK#, Fleissner A#, Helming L#, Inoue N#, Podbilewicz B*, Wang H#, Wong M#. Genetic basis of cell–cell fusion mechanisms. Trends Genet, 2013, 29(7), 427-437. (#, equal contribution.) (invited review).