现任领导-- 干细胞与再生医学创新研究院

机构简介

现任领导

赵同标

[研究员]

干细胞与免疫学研究组

联系方式 tbzhao@ioz.ac.cn +86-10-64805262 http://rpb.ioz.cas.cn/yjz/zhaotongbiao/

教育经历

2004年毕业于中科院西高所获博士学位。

工作经历

毕业后进入中科院生物物理所博士后流动站从事免疫学研究，2006年获该所副研究员任职资格；2007年至2010年在加州大学圣地亚哥分校做博士后，从事多能干细胞研究，2010年任该校Assistant Specialist III；2012年加入中科院动物研究所，组建干细胞与免疫学实验室。

研究方向

研究组围绕干细胞基础与临床转化研究中的免疫学问题，重点聚焦于以下研究方向：（1）干细胞临床转化的免疫学基础；（2）干细胞命运决定的物质能量代谢基础；（3）多能干细胞的定向分化。

代表性发表论文

Zhou J#, Jin L, Wang F, Zhang Y, Liu B, Zhao T*. Chimeric antigen receptor T (CAR-T) cells expanded with IL-7/IL-15 mediate superior antitumor effects. Protein Cell, 2019, 10(10): 764-769. DOI: 10.1007/s13238-019-0643-y
Gu H#, Shi X#, Liu C#, Wang C#, Sui N, Zhao Y, Gong J, Wang F, Zhang H, Li W*, Zhao T*. USP8 maintains embryonic stem cell stemness via deubiquitination of EPG5. Nature Communications, 2019, 10(1): 1465. DOI: 10.1038/s41467-019-09430-4
Gong J#, Gu H#, Zhao L#, Wang L, Liu P, Wang F, Xu H, Zhao T*. Phosphorylation of ULK1 by AMPK is essential for mouse embryonic stem cell self-renewal and pluripotency. Cell Death Disease, 2018, 9(2): 38. DOI: 10.1038/s41419-017-0054-z
Liu P#, Liu K#, Gu H, Wang W, Gong J, Zhu Y, Zhao Q, Cao J, Han C, Gao F, Chen Q, Li W, Jiao J, Hu B, Zhou Q, Zhao T*. High autophagic flux guards ESC identity through coordinating autophagy machinery gene program by FOXO1. Cell Death Differentiation, 2017, 24(10): 1672-1680. DOI: 10.1038/cdd.2017.90
Sun H#, Cao J#, Zhao L#, Zhu S, Chen S, Li Y, Zhao B, Zhao T*. PIM2 regulates stemness through phosphorylation of 4E-BP1. Science Bulletin, 2017, 62(10): 679-685. (Cover story) DOI: 10.1016/j.scib.2017.04.018
Liu K#, Zhao Q#, Liu P#, Cao J, Gong J, Wang C, Wang W, Li X, Sun H, Zhang C, Li Y, Jiang M, Zhu S, Sun Q, Jiao J, Hu B, Zhao X, Li W, Chen Q, Zhou Q*, Zhao T*. ATG3-dependent autophagy mediates mitochondrial homeostasis in pluripotency acquirement and maintenance. Autophagy, 2016, 12(11): 2000-2008. DOI: 10.1080/15548627.2016.1212786
Zhu S, Cao J, Sun H, Liu K, Li Y, Zhao T*. p18 inhibits reprogramming through inactivation of Cdk4/6. Scientific Reports, 2016, 6: 31085. DOI: 10.1038/srep31085
Zhang C, Cao J, Li X, Xu H, Wang W, Wang L, Zhao X, Li W, Jiao J, Hu B, Zhou Q*, Zhao T*. Treatment of multiple sclerosis by transplantation of neural stem cells derived from induced pluripotent stem cells. Science China Life Sciences, 2016, 59(9): 950-957. DOI: 10.1007/s11427-016-0114-9
Zhao T#, Zhang Z#, Westenskow P#, Todorova D, Hu Z, Lin T, Rong Z, Kim J, He J, Wang M, Clegg D, Yang Y, Zhang K, Friedlander M, Xu Y*. Humanized mice reveal differential immunogenicity of cells derived from autologous induced pluripotent stem cells. Cell Stem Cell, 2015, 17(3): 353-359. DOI: 10.1016/j.stem.2015.07.021
Wang L#, Cao J#, Wang Y#, Lan T#, Liu L, Wang W, Jin N, Gong J, Zhang C, Teng F, Yan G, Li C, Li J, Wan H, Hu B, Li W, Zhao X, Qi Z*, Zhao T*, Zhou Q*. Immunogenicity and functional evaluation of iPSC-derived organs for transplantation. Cell Discovery, 2015, 1: 15015. DOI: 10.1038/celldisc.2015.15
Zhao T, Zhang Z, Rong Z, Xu Y*. Immunogenicity of induced pluripotent stem cells. Nature, 2011, 474(7350): 212-216. DOI: 10.1038/nature10135

Highlighted by Nature (Nature 474:165); Nature Medicine (Nature Medicine 17: 670)
Recommended by Faculty of 1000 (F1000.com/11136956)
Reported by Nature, Science, New York Time, New Scientist, ScienceDaily, UK Guardian, USA today et al.

Hou Q#, Zhao T#, Zhang H, Lu H, Zhang Q, Sun L, Fan Z*. Granzyme H induces apoptosis of target tumor cells characterized by DNA fragmentation and Bid-dependent mitochondrial damage. Molecular Immunology, 2008, 45(4): 1044-1055. DOI: 10.1016/j.molimm.2007.07.032
Zhao T#, Zhang H#, Guo Y, Fan Z*. Granzyme K directly processes bid to release cytochrome c and endonuclease G leading to mitochondria-dependent cell death. Journal of Biological Chemistry, 2007, 282(16): 12104-12111. DOI: 10.1074/jbc.M611006200
Zhao T#, Zhang H, Guo Y, Zhang Q, Hua G, Lu H, Hou Q, Liu H, Fan Z*. Granzyme K cleaves the nucleosome assembly protein SET to induce single-stranded DNA nicks of target cells. Cell Death and Differentiation, 2007, 14(3): 489-499. DOI: 10.1038/sj.cdd.4402040.