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Polyurethane-gelatin methacryloyl hybrid ink for 3D printing of biocompatible and tough vascular networks

2022-06-16

论文题目:Polyurethane-gelatin methacryloyl hybrid ink for 3D printing of biocompatible and tough vascular networks

作者:Huang Y, Zhao H, Wang X, Liu X, Gao Z, Bai H, Lv F, Gu Q, Wang S

日期:2022.6

发表期刊:Chem Commun

doi:10.1039/d2cc02176e

摘要:

    A polyurethane-gelatin methacryloyl (PU-GelMA) hybrid ink was developed as a photo-crosslinkable elastic hydrogel. With the additional acrylic monomer, the ink can be tuned to accommodate elasticity and printability. Attributed to the shear-thinning properties of GelMA, PU-GelMA was preferable for extrusion printing. 3D-constructs were printed by direct extrusion or by using a sacrificial scaffold to resemble the vascular networks. The proliferation of endothelial cells on the PU-GelMA hydrogel indicated decent biocompatibility and potential utilization in artificial vessels.




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