致一研究员-- 干细胞与再生医学创新研究院

研究队伍

致一研究员

冯桂海

[致一研究员]

生殖工程研究组

联系方式 fenggh@ioz.ac.cn +86-10-64807297

教育经历

2007年6月，在山东大学（威海）海洋学院获生物科学专业学士学位;

　　2010年6月，在军事医学科学院生物工程研究所获生物安全专业硕士学位（指导老师：王玉民研究员）;

　　2014年6月，在中国科学院遗传与发育生物学研究所获生物信息学专业博士学位（指导老师：王秀杰研究员）。

工作经历

2014年8月至2018年1月，在中国科学院动物研究所进行博士后训练（合作导师：周琪研究员）;

　　2018年1月至今，在中国科学院动物研究所任副研究员。

研究方向

以小鼠及非人灵长类动物为模型，借助高通量测序及系统生物学手段研究胚胎发育的调控机制。

代表性发表论文

（#共同第一作者）

Feng GH#, Tong M#, Xia B#, Luo GZ, Wang M, Xie D, Wan H, Zhang Y, Zhou Q, Wang XJ. Ubiquitously expressed genes participate in cell-specific functions via alternative promoter usage. EMBO Rep. 2016 Sep;17(9):1304-13.
Wang J#, Wang L#, Feng G#, Wang Y#, Li Y, Li X, Liu C, Jiao G, Huang C, Shi J, Zhou T, Chen Q, Liu Z, Li W, Zhou Q. Asymmetric Expression of LincGET Biases Cell Fate in Two-Cell Mouse Embryos. Cell. 2018 Dec 13;175(7):1887-1901.
Li ZK#, Wang LY#, Wang LB#, Feng GH#, Yuan XW#, Liu C, Xu K, Li YH, Wan HF, Zhang Y, Li YF, Li X, Li W, Zhou Q, Hu BY. Generation of Bimaternal and Bipaternal Mice from Hypomethylated Haploid ESCs with Imprinting Region Deletions. Cell Stem Cell. 2018 Nov 1;23(5):665-676.
Zhang W#, Wan H#, Feng G#, Qu J#, Wang J, Jing Y, Ren R, Liu Z, Zhang L, Chen Z, Wang S, Zhao Y, Wang Z, Yuan Y, Zhou Q, Li W, Liu GH, Hu B. SIRT6 deficiency results in developmental retardation in cynomolgus monkeys. Nature. 2018 Aug;560(7720):661-665.
Li TD#, Feng GH#, Li YF#, Wang M#, Mao JJ, Wang JQ, Li X, Wang XP, Qu B, Wang LY, Zhang XX, Wan HF, Cui TT, Wan C, Liu L, Zhao XY, Hu BY, Li W, Zhou Q. Rat embryonic stem cells produce fertile offspring through tetraploid complementation. Proc Natl Acad Sci U S A. 2017 Nov 7;114(45):11974-9.
Xu K#, Yang Y#, Feng GH#, Sun BF#, Chen JQ#, Li YF, Chen YS, Zhang XX, Wang CX, Jiang LY, Liu C, Zhang ZY, Wang XJ, Zhou Q, Yang YG, Li W. Mettl3-mediated m6A regulates spermatogonial differentiation and meiosis initiation. Cell Res. 2017 Sep;27(9):1100-14. (cover story)
Li Z#, Wan H#, Feng G#, Wang L#, He Z, Wang Y, Wang XJ, Li W, Zhou Q, Hu B. Birth of fertile bimaternal offspring following intracytoplasmic injection of parthenogenetic haploid embryonic stem cells. Cell Res. 2016 Jan;26(1):135-8.
Li J#, Wang C#, Feng G#, Zhang L#, Chen G, Sun H, Wang J, Zhang Y, Zhou Q, Li W. Rbm14 maintains the integrity of genomic DNA during early mouse embryogenesis via mediating alternative splicing. Cell Prolif. 2020 Jan;53(1):e12724.
Mao J, Xu K, Han J, Feng G, Zhang Y, Li W. Rapid construction of a whole-genome mutant library by combining haploid stem cells and inducible self-inactivating PiggyBac transposon. Protein Cell. 2020 Mar 19.
Fu R, Yu D, Ren J, Li C, Wang J, Feng G, Wang X, Wan H, Li T, Wang L, Zhang Y, Hai T, Li W, Zhou Q. Domesticated cynomolgus monkey embryonic stem cells allow the generation of neonatal interspecies chimeric pigs. Protein Cell. 2020 Feb;11(2):97-107.
Li Z, Wu J, Wang L, Han W, Yu J, Liu X, Wang Y, Zhang Y, Feng G, Li W, Stacey GN, Gu Q, Hu B, Wang L, Zhou Q, Hao J. Generation of qualified clinical-grade functional hepatocytes from human embryonic stem cells in chemically defined conditions. Cell Death Dis. 2019 Oct 10;10(10):763.
Li Y, Wang L, Zhang L, He Z, Feng G, Sun H, Wang J, Li Z, Liu C, Han J, Mao J, Li P, Yuan X, Jiang L, Zhang Y, Zhou Q, Li W. Cyclin B3 is required for metaphase to anaphase transition in oocyte meiosis I. J Cell Biol. 2019 May 6;218(5):1553-1563.
Teng F, Li J, Cui T, Xu K, Guo L, Gao Q, Feng G, Chen C, Han D, Zhou Q, Li W. Enhanced mammalian genome editing by new Cas12a orthologs with optimized crRNA scaffolds. Genome Biol. 2019 Feb 5;20(1):15.
Cui T, Jiang L, Li T, Teng F, Feng G, Wang X, He Z, Guo L, Xu K, Mao Y, Wang L, Yuan X, Wang L, Li W, Zhou Q. Derivation of Mouse Haploid Trophoblast Stem Cells. Cell Rep. 2019 Jan 8;26(2):407-414.
Zhang W, Feng G, Wang L, Teng F, Wang L, Li W, Zhang Y, Zhou Q. MeCP2 deficiency promotes cell reprogramming by stimulating IGF1/AKT/mTOR signaling and activating ribosomal protein-mediated cell cycle gene translation. J Mol Cell Biol. 2018 Dec 1;10(6):515-526.
Teng F, Cui T, Feng G, Guo L, Xu K, Gao Q, Li T, Li J, Zhou Q, Li W. Repurposing CRISPR-Cas12b for mammalian genome engineering. Cell Discov. 2018 Nov 27;4:63.
Chen G, Zhang D, Zhang L, Feng G, Zhang B, Wu Y, Li W, Zhang Y, Hu B. RBM14 is indispensable for pluripotency maintenance and mesoderm development of mouse embryonic stem cells. Biochem Biophys Res Commun. 2018 Jun 18;501(1):259-265.
Zhang Y, Guo L, Li Y, Feng GH, Teng F, Li W, Zhou Q. MicroRNA-494 promotes cancer progression and targets adenomatous polyposis coli in colorectal cancer. Mol Cancer. 2018 Jan 5;17(1):1.
Zhang Y, Cui P, Li Y, Feng G, Tong M, Guo L, Li T, Liu L, Li W, Zhou Q. Mitochondrially produced ATP affects stem cell pluripotency via Actl6a-mediated histone acetylation. FASEB J. 2018 Apr;32(4):1891-1902.
Wang X, Li T, Cui T, Yu D, Liu C, Jiang L, Feng G, Wang L, Fu R, Zhang X, Hao J, Wang Y, Wang L, Zhou Q, Li W, Hu B. Human embryonic stem cells contribute to embryonic and extraembryonic lineages in mouse embryos upon inhibition of apoptosis. Cell Res. 2018 Jan;28(1):126-129.
He ZQ, Xia BL, Wang YK, Li J, Feng GH, Zhang LL, Li YH, Wan HF, Li TD, Xu K,Yuan XW, Li YF, Zhang XX, Zhang Y, Wang L, Li W, Zhou Q. Generation of mouse haploid somatic cells by small molecules for genome-wide genetic screening. Cell Rep. 2017 Aug 29;20(9):2227-37.
Zhang Y, Feng GH, Xu K, Wang L, Cui P, Li Y, Wang C, Teng F, Hao J, Wan HF, Tan Y, Wang XJ, Zhou Q. A non-invasive method to determine the pluripotent status of stem cells by culture medium microRNA expression detection. Sci Rep. 2016 Mar 1;6:22380.
Zhou Q, Wang M, Yuan Y, Wang X, Fu R, Wan H, Xie M, Liu M, Guo X, Zheng Y, Feng GH, Shi Q, Zhao XY, Sha J, Zhou Q. Complete meiosis from embryonic stem cell-derived germ cells in vitro. Cell Stem Cell. 2016 Mar 3;18(3):330-40.
Li X, Cui XL, Wang JQ, Wang YK, Li YF, Wang LY, Wan HF, Li TD, Feng GH, Shuai L, Li ZK, Gu Q, Hao J, Wang L, Zhao XY, Liu ZH, Wang XJ, Li W, Zhou Q. Generation and application of mouse-rat allodiploid embryonic stem cells. Cell. 2016 Jan 14;164(1-2):279-292.
Chen Q, Yan M, Cao Z, Li X, Zhang Y, Shi J, Feng GH, Peng H, Zhang X, Zhang Y, Qian J, Duan E, Zhai Q, Zhou Q. Sperm tsrnas contribute to intergenerational inheritance of an acquired metabolic disorder. Science. 2016 Jan 22;351(6271):397-400.
Luo GZ, Hafner M, Shi Z, Brown M, Feng GH, Tuschl T, Wang XJ, Li X. Genome-wide annotation and analysis of zebra finch microRNA repertoire reveal sex-biased expression. BMC Genomics. 2012 Dec 26;13:727.