致一研究员-- 干细胞与再生医学创新研究院

研究队伍

致一研究员

万海峰

[致一研究员]

生殖工程组

联系方式 wanhf@ioz.ac.cn

教育经历

2008/05-2012/11 中国科学院动物研究所发育生物学博士学位

2001/09-2004/07 中国人民解放军军事医学科学院预防兽医学硕士学位

1997/09-2001/07 中国人民解放军军需大学预防兽医学学士学位

工作经历

2014/12 - 至今中国科学院动物研究所工作

2012/11-2014/11 中国科学院动物研究所博士后

2004/09-2007/12 兰州军区疾病预防控制中心实验室科员

研究方向

从事非人灵长类相关的科研项目研究。

代表性发表论文

1，Wan, H#, He, Z#, Dong, M, Gu, T, Luo, G, Teng, F, Xia, B, Li, W, Feng, C, Li, X, Li, T, Shuai, L, Fu, R, Wang, L, Wang, X-J, Zhao, X*, and Zhou, Q* Parthenogenetic haploid embryonic stem cells produce fertile mice. Cell Res. 2013, 23, 1330-1333（排名第一）

2，Li, W#, Shuai, L#, Wan, H#, Dong, M#, Wang, M, Sang, L, Feng, C, Luo, G, Li, T, Li,X, Wang, L, Zheng, Q, Sheng, C, Wu, H, Liu, Z, Liu, L, Wang, X, Zhao, X*, and Zhou, Q*. Androgenetic haploid embryonic stem cells produce live transgenic mice. Nature. 2012，490, 407-411（共同第一排序第三）

3，Li Z#, Wan H#, Feng G#, Wang L#, He Z, Wang Y, Wang XJ, Li W, Zhou Q*, Hu B*. Birth of fertile bimaternal offspring following intracytoplasmic injection of parthenogenetic haploid embryonic stem cells. Cell Res. 2016, Jan; 26(1):135-8（共同第一排序第二）

4，Li W#, Li X#, Li TD#, Jiang MG#, Wan HF, Luo GZ, Feng CJ, Cui XL, Teng F, Yuan Y, Zhou Q, Gu Q, Shuai L, Sha JH, Xiao YM, Wang L, Liu ZH, Wang XJ, Zhao XY, Zhou Q*. Genetic modification and screening in the rat using haploid embryonic stem cells. (2014) Cell Stem Cell 14(3):404-414.（参与，排序 5/20）

5，Li X#, Cui XL#, Wang JQ #, Wang YK, Li YF, Wang LY, Wan HF, Li TD, Feng GH, Shuai L, Li ZK, Gu Q, Hao J, Wang L, Zhao XY, Liu ZH, Wang XJ, Li W*, Zhou Q*. Generation and Application of Mouse-Rat Allodiploid Embryonic Stem Cells. (2016) Cell 164(1–2): 279–292.（参与，排序 7/18）

6，Li ZK#, Wang LY#, Wang LB#, Feng GH#, Yuan XW#, Liu C, Xu K, Li YH, Wan HF, Zhang Y, Li YF, Li X, Li W*, Zhou Q*, Hu BY*. Generation of Bimaternal and Bipaternal Mice from Hypomethylated Haploid ESCs with Imprinting Region Deletions. (2018) Cell Stem Cell 23(5):665-676（参与，排序 9/15）

7，Wan H#, Feng C#, Teng F, Yang S, Hu B, Niu Y, Xiang AP, Fang W, Ji W, Li W, Zhao X*, Zhou Q*. One-step generation of p53 gene biallelic mutant cynomolgus monkey via the CRISPR/Cas system. Cell Res. 2015, Feb; 25(2):258-61（第一作者）

8，Zhang W#, Wan H#, Feng G#, Qu J#, Wang J, Jing Y, Ren R, Liu Z, Zhang L, Chen Z, Wang S, Zhao Y, Wang Z, Yuan Y, Zhou Q, Li W*, Liu GH*, Hu B*. SIRT6 deficiency results in developmental retardation in cynomolgus monkeys. Nature. 2018 Aug; 560(7720):661-665（共同第一排序第二）

9，Yuan Y#, Zhou Q#, Wan H#, Shen B#, Wang X, Wang M, Feng C, Xie M, Gu T, Zhou T, Fu R, Huang X, Zhou Q, Sha J, Zhao XY. Generation of fertile offspring from Kit(w)/Kit(wv) mice through differentiation of gene corrected nuclear transfer embryonic stem cells. Cell Res. 2015 Jul; 25(7): 851-63（共同第一排序第三）

10，Huaixiao Ma#, JingleiZhai#, Haifeng Wan#, Xiangxiang Jiang #, Xiaoxiao Wang, Lin Wang, Yunlong Xiang, Xiechao He, Zhen-Ao Zhao, Bo Zhao, Ping Zheng, Lei Li, Hongmei Wang. In vitro culture of cynomolgus monkey embryos beyond early gastrulation. Science. 2019 Nov 15;366(6467).（共同第一排序第三）

11，Zhou Q#, Wang M#, Yuan Y#, Wang X, Fu R, Wan H, Xie M, Liu M, Guo X, Zheng Y,Feng G, Shi Q, Zhao XY*, Sha J*, Zhou Q*. Complete Meiosis from Embryonic Stem Cell-Derived Germ Cells In Vitro. (2016) Cell Stem Cell 18(3):330-340（参与，排序 6/15）

12，Fu R#, Yu D#, Ren J#, Li C#, Wang J, Feng G, Wang X, Wan H, Li T, Wang L, Zhang Y, Hai T*, Li W*, Zhou Q*. (2019) Domesticated cynomolgus monkey embryonic stem cells allow the generation of neonatal interspecies chimeric pigs. Protein Cell. 2019 Nov 28.（参与，排序 8/14）