[致一研究员]
李静宜博士致力于衰老的功能基因组学研究,综合运用多组学技术解析衰老及相关疾病的发生发展机制,挖掘新型衰老干预靶标,其工作加深了对灵长类干细胞与器官衰老的认识。
1. S. Wang#, Y. Zheng#, J. Li#, Y Yang#, W. Zhang#, M. Song, Z. Liu, Z. Min, H. Hu, Y. Jing, X. He, L. Sun, L. Ma, C. R. Esteban, P. Chan, J. Qiao, Q. Zhou, J. C. I. Belmonte, J. Qu, F. Tang, and G.-H. Liu, “Single-cell transcriptomic atlas of primate ovarian aging,” Cell (IF = 41.6), vol. 180, no. 3, pp. 585-600, 2020. (Cover story)
2. W. Zhang#, J. Li#, K. Suzuki#, J. Qu#, P. Wang, J. Zhou, X. Liu, R. Ren, X. Xu, A. Ocampo, T. Yuan, J. Yang, Y. Li, L. Shi, D. Guan, H. Pan, S. Duan,Z. Ding, M. Li, F. Yi, R. Bai, Y. Wang, C. Chen, F. Yang, X. Li, Z. Wang, E. Aizawa, A. Goebl, R. D. Soligalla, P. Reddy, C. R. Esteban, F. Tang, G.-H. Liu, and J. C. I. Belmonte, “A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging,” Science (IF = 47.7), vol. 348, no. 6239, pp. 1160–1163, 2015.
3. J. Li#, Y. Zheng#, P. Yan#, M. Song#, S. Wang#, L. Sun, Z. Liu, S. Ma, P. Chan, Q. Zhou, J. C. I. Belmonte, W. Zhang, G.-H. Liu, F. Tang, J. Qu, “A Single-cell Transcriptomic Atlas of Primate Pancreatic Islet Aging,” National Science Review (IF = 16.7), vol. 8, no. 2, 2021. DOI: 10.1093/nsr/nwaa127.
4. J. Li#, X. Zhou#, X. Liu#, J. Ren#, J. Wang, W. Wang, Y. Zheng, X. Shi, T. Sun, Z. Li, A. Kang, F. Tang, L. Wen, and W. Fu, “Detection of Colorectal Cancer in Circulating Cell-Free DNA by Methylated CpG Tandem Amplification and Sequencing,” Clinical Chemistry (IF = 8.3), vol. 65, no. 7, pp. 916-926, 2019.
5. J. Yang#, J. Li#, K. Suzuki#, X. Liu, J. Wu, W. Zhang, R. Ren, W. Zhang, P. Chan, J. C. I. Belmonte, J. Qu, F. Tang, and G.-H. Liu, “Genetic enhancement in cultured human adult stem cells conferred by a single nucleotide recoding,” Cell Research (IF = 25.6), vol. 27, no. 9, pp. 1178–1181, 2017.