致一研究员-- 干细胞与再生医学创新研究院

研究队伍

致一研究员

李静宜

[致一研究员]

衰老与再生研究组

联系方式 lijingyi@ioz.ac.cn

教育经历

2008-2012 年河北农业大学生物技术学士学位

2012-2017 年北京大学细胞生物学博士学位

工作经历

2017年7月-2019年8月中国科学院生物物理研究所，项目副研究员

2019年9月至今中国科学院动物研究所，副研究员

研究方向

李静宜博士致力于衰老的功能基因组学研究，综合运用多组学技术解析衰老及相关疾病的发生发展机制，挖掘新型衰老干预靶标，其工作加深了对灵长类干细胞与器官衰老的认识。

代表性发表论文

（#共同第一作者）

1. Sun S^#, Li J^#, Wang S^#, Li J^#, Ren J^#, Bao Z^#, Sun L^#, Ma X^#, Zheng F, Ma S, Sun L, Wang M, Yu Y, Ma M, Wang Q, Chen Z, Ma H, Wang X, Wu Z, Zhang H, Yan K, Yang Y, Zhang Y, Zhang S, Lei J, Teng ZQ, Liu CM, Bai G, Wang YJ, Li J, Wang X, Zhao G, Jiang T, Belmonte JCI, Qu J, Zhang W, Liu GH. CHIT1-positive microglia drive motor neuron aging in the primate spinal cord. Nature. 624(7992):611-620.

2. Wang S^#, Zheng Y^#, Li J^#, Yu Y^#, Zhang W^#, Song M, Liu Z, Min Z, Hu H, Jing Y, He X, Sun L, Esteban C, Chan P, Qiao J, Zhou Q, Belmonte JC, Jing Qu, Tang F, Liu GH. Single-cell transcriptomic atlas of primate ovarian aging. Cell. 2020. 180(3): 585-600. (Cover story)

3. Zhang W^#, Li J^#, Suzuki K^#, Qu J^#, Wang P, Zhou J, Liu X, Ren R, Xu X, Ocampo A, Yuan T, Yang J, Li Y, Shi L, Guan D, Pan H, Duan S, Ding Z, Li M, Yi F, Bai R, Wang Y, Chen C, Yang F, Li X, Wang Z, Aizawa E, Goebl A, Soligalla RD, Reddy P, Esteban CR, Tang F, Liu GH, Belmonte JC. A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging. Science. 2015. 348(6239):1160-1163.

4. Li J^#, Zheng Y^#, Yan P^#, Song M^#, Wang S^#, Sun L, Liu Z, Ma S, Chan P, Zhou Q, Belmonte JC, Zhang W, Liu GH, Tang F, Qu J. A single-cell transcriptomic atlas of primate pancreatic islet aging. National Science Review. 2021. 8(2):nwaa127.

5. Li J^#, Zhou X^#, Liu X^#, Ren J^#, Wang J, Wang W, Zheng Y, Shi X, Sun T, Li Z, Kang A, Tang F, Wen L, Fu W. Detection of colorectal cancer in circulating cell-free DNA by methylated CpG tandem amplification and sequencing. Clinical Chemistry. 2019. 65(7):916-926.

6. Yang J^#, Li J^#, Suzuki K^#, Liu X, Wu J, Zhang W, Ren R, Zhang W, Chan P, Belmonte JC, Qu J, Tang F, Liu GH. Genetic enhancement in cultured human adult stem cells conferred by a single nucleotide recoding. Cell Research. 2017. 27(9):1178-1181.

7. Wen L^#, Li J^#, Guo H^#, Liu X^#, Zheng S, Zhang D, Zhu W, Qu J, Guo L, Du D, Jin X, Zhang Y, Gao Y, Shen J, Ge H, Tang F, Huang Y, Peng J. Genome-scale detection of hypermethylated CpG islands in circulating cell-free DNA of hepatocellular carcinoma patients. Cell Research. 2015. 25(11):1250-1264.