研究队伍

致一研究员

王昱凯

[致一研究员]

生殖工程研究组

联系方式 wangyukai@ioz.ac.cn

教育经历

2001.9-2005.7,南京工业大学,生物学学士
2005.9-2008.7,山东大学,理学硕士
2008.9-2011.7,山东大学,理学博士

工作经历

2011.7 -2015.6,中国科学院动物研究所,博士后
2015.7-2019.6,中国科学院动物研究所,助理研究员
2019.6-至今,中国科学院动物研究所,副研究员

研究方向

王昱凯博士致力于细胞命运调控和神经再生研究。利用创新性技术,开发重大神经疾病的体外模型和细胞替代疗法,并进一步开展临床与转化研究。

代表性发表论文

1. Zhao YL#, Wu J, Li D, Liu J, Chen WQ, Hou ZR, Liu KL, Jiang LL, Chen XW, Wang L, Hu BY, Zong FR*, Wang YK*, Wang YL*. Human ESC-derived immunity- and matrix- regulatory cells ameliorated white matter damage and vascular cognitive impairment in rats subjected to chronic cerebral hypoperfusion. Cell Proliferation. 2022, Apr 19;e13223.

2. Sun Y#, Feng L#, Liang LM#, Stacey GN, Wang CQ, Wang YK*, Hu BY*. Neuronal cell-based medicines from pluripotent stem cells: development, production, and pre-clinical assessment. STEM CELLS Translational Medicine. 2021; Nov;10 Suppl 2(Suppl 2):S31-S40.

3. Liu J#, Hou ZR#, Wu J#, Liu KL, Li D, Gao TT, Liu WJ, An B, Sun Y, Mo F, Wang L, Wang YK*, Hao J*, Hu BY*. Infusion of hESC derived Immunity-and-matrix regulatory cells improves cognitive ability in early-stage AD mice. Cell Proliferation. 2021; Aug;54(8):e13085.

4. Wang YK#, Zhu WW#, Wu MH#, Wu YH, Liu ZX, Liang LM, Sheng C, Hao J, Wang L, Li W, Zhou Q, Hu BY, Human Clinical-Grade Parthenogenetic ESC-Derived Dopaminergic Neurons Recover Locomotive Defects of Nonhuman Primate Models of Parkinson's Disease, Stem Cell Reports, 2018, 11(1): 171-182

5. Wang JQ#, Wang LY#, Feng GH#, Wang YK#, Li YF, Li X, Liu C, Jiao GY, Huang C, Shi JC, Zhou T, Chen Q, Liu ZH, Li W, Zhou Q, Asymmetric Expression of LincGET Biases Cell Fate in Two-Cell Mouse Embryos, Cell, 2018, 175(7): 1887-1901