研究队伍

研究员

周琪

[中国科学院院士]

生殖工程研究组

联系方式 zhouqi@ioz.ac.cn 010-64807299 http://rpb.ioz.cas.cn/yjz/zhouqi/

教育经历

1987年-1991年

中国东北农业大学

生物工程系

学士学位

1991年-1994年

中国东北农业大学

生物工程系

硕士学位

1994年-1996年

中国东北农业大学

生物工程系

博士学位

工作经历

1997年-1999年

中国科学院发育生物学研究所, 博士后及副研究员

1999年-2002年

法国国家农业科学研究院(INRA), 博士后及项目组长

2002年-至今

中国科学院动物研究所干细胞与生殖生物学国家重点实验室, 研究员

研究方向

研究组主要从事生殖、发育、干细胞的基础研究,并致力于推动再生医学和干细胞的转化应用。

代表性发表论文

Zhou Q, Renard JP#, Le Friec G, Brochard V, Beaujean N, Cherifi Y, Fraichard A, Cozzi J. (2003) Generation of fertile cloned rats by regulating oocyte activation. Science 302(5648):1179.

Zhao XY*, Li W*, Lv Z*, Liu L, Tong M, Hai T, Hao J, Guo CL, Ma QW, Wang L, Zeng F#, Zhou Q#. (2009) iPS cells produce viable mice through tetraploid complementation. Nature 461(7260):86-90.

Liu L*, Luo GZ*, Yang W*, Zhao X*, Zheng Q, Lv Z, Li W, Wu HJ, Wang L, Wang XJ#, Zhou Q#. (2010) Activation of the imprinted Dlk1-Dio3 region correlates with pluripotency levels of mouse stem cells. J. Biol. Chem. 285(25):19483-19490.

Li W*, Shuai L*, Wan H*, Dong M*, Wang M, Sang L, Feng C, Luo GZ, Li T, Li X, Wang L, Zheng QY, Sheng C, Wu HJ, Liu Z, Liu L, Wang L, Wang XJ, Zhao XY#, Zhou Q#. (2012) Androgenetic haploid embryonic stem cells produce live transgenic mice. Nature 490(7420):407-411.

Li W*, Teng F*, Li T, Zhou Q#. (2013) Simultaneous generation and germline transmission of multiple gene mutations in rat using CRISPR-Cas systems. Nat. Biotechnol. 31(8):684–686.

Hai T*, Teng F*, Guo R, Li W, Zhou Q#. (2014) One-step generation of knockout pigs by zygote injection of CRISPR/Cas system. Cell Res. 24(3):372-375.

Li W*, Li X*, Li T*, Jiang MG*, Wan H, Luo GZ, Feng C, Cui X, Teng F, Yuan Y, Zhou Q, Gu Q, Shuai L, Sha J, Xiao Y, Wang L, Liu Z, Wang XJ, Zhao XY, Zhou Q#. (2014) Genetic modification and screening in rat using haploid embryonic stem cells. Cell Stem Cell 14(3):404-414.

Li X*, Wang JQ*, Wang LY*, Wan HF, Li YF, Li TD, Wang YK, Shuai L, Mao YH, Cui XL, Wang L, Liu ZH, Li W, Zhou Q#. (2015) Co-participation of paternal and maternal genomes before the blastocyst stage is not required for full-term development of mouse embryos. J Mol Cell Biol. 7(5):486-488.

Chen T*, Hao YJ*, Zhang Y*, Li MM*, Wang M, Han W, Wu Y, Lv Y, Hao J, Wang L, Li A, Yang Y, Jin KX, Zhao X, Li Y, Ping XL, Lai WY, Wu LG, Jiang G, Wang HL, Sang L, Wang XJ#, Yang YG#, Zhou Q#. (2015) m6A RNA methylation is regulated by microRNAs and promotes reprogramming to pluripotency. Cell Stem Cell 16(3):289-301.

Wan H*, Feng C*, Teng F*, Yang S*, Hu B, Niu Y, Xiang AP, Fang W, Ji W, Li W#, Zhao X#, Zhou Q#. (2015) One-step generation of p53 gene biallelic mutant Cynomolgus monkey via the CRISPR/Cas system. Cell Res. 25(2):258-261.

Chen Q*#, Yan M*, Cao Z*, Li X*, Zhang Y*, Shi J*, Feng GH, Peng H, Zhang X, Zhang Y, Qian J, Duan E#, Zhai Q#, Zhou Q#. (2016) Sperm tsRNAs contribute to intergenerational inheritance of an acquired metabolic disorder. Science 351(6271):397-400.

Zhou Q*, Wang M*, Yuan Y*, Wang X, Fu R, Wan H, Xie M, Liu M, Guo X, Zheng Y, Feng G, Shi Q, Zhao XY#, Sha J#, Zhou Q# (2016) Complete Meiosis from Embryonic Stem Cell-Derived Germ Cells In Vitro. Cell Stem Cell 18(3):330-340.

Li X*, Cui XL*, Wang JQ*, Wang YK, Li YF, Wang LY, Wan HF, Li TD, Feng GH, Shuai L, Li ZK, Gu Q, Hao J, Wang L, Zhao XY, Liu ZH, Wang XJ, Li W#, Zhou Q#. (2016) Generation and application of mouse-rat allodiploid embryonic stem cells. Cell 164(1-2):279–292.

Gu Q*, Wang J*, Wang L*, Liu ZX, Zhu WW, Tan YQ, Han WF, Wu J, Feng CJ, Fang JH, Liu L, Wang L, Li W, Zhao XY, Hu BY, Hao J#, Zhou Q#. (2017) Accreditation of Biosafe Clinical-Grade Human Embryonic Stem Cells According to Chinese Regulations. Stem Cell Reports 9(1):366-380.

Li TD*, Feng GH*, Li YF*, Wang M*, Mao JJ, Wang JQ, Li X, Wang XP, Qu B, Wang LY, Zhang XX, Wan HF, Cui TT, Wan C, Liu L, Zhao XY, Hu BY, Li W, Zhou Q#. (2017) Rat embryonic stem cells produce fertile offspring through tetraploid complementation. Proc Natl Acad Sci U S A. 2017 Oct 23. pii: 201708710. doi: 10.1073/pnas.1708710114. [Epub ahead of print]

Li ZK*, Wang LY*, Wang LB*, Feng GH*, Yuan XW*, Liu C, Xu K, Li YH, Wan HF, Zhang Y, Li YF, Li X, Li W#, Zhou Q#, Hu BY#. (2018) Generation of Bimaternal and Bipaternal Mice from Hypomethylated Haploid ESCs with Imprinting Region Deletions. Cell Stem Cell 23(5):665-676.

Wang J*, Wang L*, Feng G*, Wang Y*, Li Y, Li X, Liu C, Jiao G, Huang C, Shi J, Zhou T, Chen Q, Liu Z, Li W#, Zhou Q#. (2018) Asymmetric Expression of LincGET Biases Cell Fate in Two-Cell Mouse Embryos. Cell 2018 Dec 13;175(7):1887-1901.e18. doi: 10.1016/j.cell.2018.11.039.

Wang L*, Wu W*, Gu Q*, Liu Z, Li Q, Li Z, Fang J, Liu W, Wu J, Zhang Y, Wang L, Xu H, Li W, Hu B, Zhou Q#, Yin Z#, Hao J#. (2019) The effect of clinical-grade retinal pigment epithelium derived from human embryonic stem cells using different transplantation strategies. Protein Cell. 2019 Jun;10(6):455-460. doi: 10.1007/s13238-018-0606-8. Epub 2019 Jan 23.

Fu R*, Yu D*, Ren J*, Li C*, Wang J, Feng G, Wang X, Wan H, Li T, Wang L, Zhang Y, Hai T#, Li W#, Zhou Q#. (2020) Domesticated cynomolgus monkey embryonic stem cells allow the generation of neonatal interspecies chimeric pigs. Protein Cell. 2020 Feb;11(2):97-107. doi: 10.1007/s13238-019-00676-8. Epub 2019 Nov 28

Wang LY*, Li ZK*, Wang LB*, Liu C*, Sun XH, Feng GH, Wang JQ, Li YF, Qiao LY, Nie H, Jiang LY, Sun H, Xie YL, Ma SN, Wan HF, Lu FL#, Li W#, Zhou Q#. Overcoming Intrinsic H3K27me3 Imprinting Barriers Improves Post-implantation Development after Somatic Cell Nuclear Transfer. Cell Stem Cell. 2020 Aug 6;27(2):315-325.e5. doi: 10.1016/j.stem.2020.05.014. Epub 2020 Jun 18.