研究队伍

研究员

韩春生

[研究员]

精原干细胞研究组

联系方式 hancs@ioz.ac.cn +86-10-64807105 http://rpb.ioz.cas.cn/yjz/hanchunsheng/

教育经历

1990年复旦大学遗传工程专业本科毕业;1993年获生殖生物学国家重点实验室生理学硕士;2000年获美国密苏里州立大学生物化学博士学位。

工作经历

2000年至2003年任美国Lexicon Genetics & Pharmaceuticals 公司高级生物信息科学家。

研究方向

目前主要从事不育治疗新技术的研发,包括两个方向:1. 生殖细胞形成、发育、减数分裂;2. 精原干细胞增殖、分化、重编程。

代表性发表论文

  1. Zhang, D., Xie, D., Lin, X., Ma, L., Chen, J., Wang, Y., Duo, S., Feng, Y., Zheng, C., Jiang, B., Ning, Y., Han, C.(2018) The transcription factor SOX30 is a key regulator of mouse spermiogenesis. Development,145. doi: 10.1242/dev.164723.
  2. Feng, Y., Ning, Y., Lin, X., Zhang, D., Liao, S., Zheng, C., Chen J., Wang Y., Ma L., Xie D., Han C.(2018) Reprogramming p53-Deficient Germline Stem Cells Into Pluripotent State by Nanog. Stem Cells Dev, 27:692-703.
  3. Hu, X., Shen, B., Liao, S., Ning, Y., Ma, L., Chen, J., Lin, X., Zhang, D., Li, Z., Zheng, C., Feng, Y., Huang, X., Han C.(2017) Gene knockout of Zmym3 in mice arrests spermatogenesis at meiotic metaphase with defects in spindle assembly checkpoint. Cell Death Di, 8:e2910.
  4. Chen, J., Cai, T., Zheng, C., Lin, X., Wang, G., Liao, S., Wang, X., Gan, H., Zhang, D., Hu, X., Wang, S., Li, Z., Feng, Y., Yang, F., and Han, C. (2017) MicroRNA-202 maintains spermatogonial stem cells by inhibiting cell cycle regulators and RNA binding proteins, Nucleic Acids Res. 45(7):4142-4157.
  5. Tu, Z., Bayazit, M. B., Liu, H., Zhang, J., Busayavalasa, K., Risal, S., Shao, J., Satyanarayana, A., Coppola, V., Tessarollo, L., Singh, M., Zheng, C., Han, C., Chen, Z., Kaldis, P., Gustafsson, J. A., and Liu, K. (2017) Speedy A-Cdk2 binding mediates initial telomere-nuclear envelope attachment during meiotic prophase I independent of Cdk2 activation, Proc Natl Acad Sci U S A, 114:592-597.
  6. Chen, M., Zhang, L., Cui, X., Lin, X., Li, Y., Wang, Y., Wang, Y., Qin, Y., Chen, D., Han, C., Zhou, B., Huff, V., and Gao, F. (2017) Wt1 directs the lineage specification of sertoli and granulosa cells by repressing Sf1 expression, Development 144, 44-53.
  7. Wang, S., Wang, X., Ma, L., Lin, X., Zhang, D., Li, Z., Wu, Y., Zheng, C., Feng, X., Liao, S., Feng, Y., Chen, J., Hu, X., Wang, M., and Han, C. (2016) Retinoic Acid Is Sufficient for the In Vitro Induction of Mouse Spermatocytes, Stem cell reports 7, 80-94.
  8. Lin, X., Han, M., Cheng, L., Chen, J., Zhang, Z., Shen, T., Wang, M., Wen, B., Ni, T., and Han, C. (2016) Expression dynamics, relationships, and transcriptional regulations of diverse transcripts in mouse spermatogenic cells, RNA biology 13, 1011-1024.
  9. Wu, Y., Hu, X., Li, Z., Wang, M., Li, S., Wang, X., Lin, X., Liao, S., Zhang, Z., Feng, X., Wang, S., Cui, X., Wang, Y., Gao, F., Hess, R. A., and Han, C. (2016) Transcription Factor RFX2 Is a Key Regulator of Mouse Spermiogenesis, Scientific reports 6, 20435.
  10. Yang, Y., Feng, Y., Feng, X., Liao, S., Wang, X., Gan, H., Wang, L., Lin, X., and Han, C. (2016) BMP4 Cooperates with Retinoic Acid to Induce the Expression of Differentiation Markers in Cultured Mouse Spermatogonia, Stem cells international 2016, 9536192.
  11. Xue, Y., Lameijer, E. W., Ye, K., Zhang, K., Chang, S., Wang, X., Wu, J., Gao, G., Zhao, F., Li, J., Han, C., Xu, S., Xiao, J., Yang, X., Ying, X., Zhang, X., Chen, W. H., Liu, Y., Zhang, Z., Huang, K., and Yu, J. (2016) Precision Medicine: What Challenges Are We Facing?, Genomics, proteomics & bioinformatics 14, 253-261.
  12. Gao, Y., Bai, X., Zhang, D., Han, C., Yuan, J., Liu, W., Cao, X., Chen, Z., Shangguan, F., Zhu, Z., Gao, F., and Qin, Y. (2016) Mammalian elongation factor 4 regulates mitochondrial translation essential for spermatogenesis, Nature structural & molecular biology 23, 441-449.
  13. #Zhu, L., #Han, C. S., Cao, Z. L., Wang, Z. B., Han, R. G., Wang, B., and Sun, Q. Y. (2015) Confocal Microscopic Analysis of the Spindle and Chromosome Configurations of in vitro-Matured Oocytes from Different Types of Polycystic Ovary Syndrome Patients, Gynecologic and obstetric investigation 80, 179-186.
  14. Wang S.,Wang Xx.,Wu Yj., and *Han, C. (2015) , IGF-1R Signaling Is Essential for the Proliferation of Cultured Mouse Spermatogonial Stem Cells by Promoting the G2/M Progression of the Cell Cycle,Stem Cells and Development 24,471-483
  15. *Han, C. (2014) , Which one is the real matchmaker for the pair?,Asian Journal of Andrology 16,667-668.
  16. Li, Y., Wang, X., Feng, X., Liao, S., Zhang, D., Cui, X., Gao, F., and *Han, C. (2014) Generation of male germ cells from mouse induced pluripotent stem cells in vitro, Stem Cell Res 12, 517-530.
  17. Gan, H., Wen, L., Liao, S., Lin, X., Ma, T., Liu, J., Song, C.-x., Wang, M., He, C., *Han, C., and *Tang, F. (2013) Dynamics of 5-hydroxymethylcytosine during mouse spermatogenesis,Nature Communications 4, 1995.
  18. Wang, F., Yang, Y., Lin, X., Wang, J. Q., Wu, Y. S., Xie, W., Wang, D., Zhu, S., Liao, Y. Q., Sun, Q., Yang, Y. G., *Guo, C., *Han, C., and *Tang, T. S. (2013) Genome-wide Loss of 5-hmC is a Novel Epigenetic Feature of Huntington's Disease, Human Molecular Genetics 22, 3641-3653.
  19. Wu, Y., Liao, S., Wang, X., Wang, S., Wang, M., and Han, C.* (2013) HSF2BP represses BNC1 transcriptional activity by sequestering BNC1 to the cytoplasm, FEBS Letters (10.1016/j.febslet.2013.04.049).
  20. Shi, Y., Zhuang, X., Xu, B., Hua, J., Liao, S., Shi, Q., Cooke, H. J., Han, C.* (2013) SYCP3-like X-linked 2 is expressed in meiotic germ cells and interacts with synaptonemal complex central element protein 2 and histone acetyltransferase TIP60, Gene(10.1016/j.gene.2013.06.033)
  21. Gan, H., Cai, T., Lin, X., Wu, Y., Wang, X., Yang, F., and Han, C.* (2013) Integrative Proteomic and Transcriptomic Analyses Reveal Multiple Post-transcriptional Regulatory Mechanisms of Mouse Spermatogenesis, Mol Cell Proteomics 12, 1144-1157.
  22. Hou, X., Zhang, W., Xiao, Z., Gan, H., Lin, X., Liao, S., and Han, C.* (2012) Mining and characterization of ubiquitin E3 ligases expressed in the mouse testis, BMC Genomics13, 495.
  23. Zhang, Y., Wang, S., Wang, X., Liao, S., Wu, Y., and Han, C.* (2012) Endogenously produced FGF2 is essential for the survival and proliferation of cultured mouse spermatogonial stem cells, Cell Research 22, 773-776.
  24. Gan, H., Lin, X., Zhang, Z., Zhang, W., Liao, S., Wang, L., and Han, C.* (2011) piRNA profiling during specific stages of mouse spermatogenesis, RNA 17, 1191-1203.
  25. Zhuang, X. J., Hou, X. J., Liao, S. Y., Wang, X. X., Cooke, H. J., Zhang, M., and Han, C.* (2011) SLXL1, a novel acrosomal protein, interacts with DKKL1 and is involved in fertilization in mice, PLoS One 6, e20866.
  26. Shi, Y. Q., Liao, S. Y., Zhuang, X. J., and Han, C. S.* (2011) Mouse Fem1b interacts with and induces ubiquitin-mediated degradation of Ankrd37, Gene 485, 153-159.
  27. Liu, Z., Lin, X., Cai, Z., Zhang, Z., Han, C., Jia, S., Meng, A., and Wang, Q. (2011) Global identification of SMAD2 target genes reveals a role for multiple co-regulatory factors in zebrafish early gastrulas, The Journal of biological chemistry 286, 28520-28532.
  28. Liu, H., Wang, B., and Han, C.* (2011) Meta-analysis of genome-wide and replication association studies on prostate cancer, The Prostate 71, 209-224.
  29. Yang, Y., and Han, C.* (2010) GDNF stimulates the proliferation of cultured mouse immature Sertoli cells via its receptor subunit NCAM and ERK1/2 signaling pathway, BMC cell biology 11, 78.
  30. Shi, Y. Q., Li, Y. C., Hu, X. Q., Liu, T., Liao, S. Y., Guo, J., Huang, L., Hu, Z. Y., Tang, A. Y., Lee, K. F., Yeung, W. S., Han, C. S.*, and Liu, Y. X. (2009) Male germ cell-specific protein Trs4 binds to multiple proteins, BBRC388, 583-588.
  31. Nian, H., Zhang, W., Shi, H., Zhao, Q., Xie, Q., Liao, S., Zhang, Y., Zhang, Z., Wang, C., and Han, C.* (2008) Mouse RING finger protein Rnf133 is a testis-specific endoplasmic reticulum-associated E3 ubiquitin ligase, Cell research 18, 800-802.
  32. Zhang, K., Shang, Y., Liao, S., Zhang, W., Nian, H., Liu, Y., Chen, Q., and Han, C.* (2007) Uncoupling protein 2 protects testicular germ cells from hyperthermia-induced apoptosis, BBRC 360, 327-332.
  33. Nian, H., Fan, C., Liao, S., Shi, Y., Zhang, K., Liu, Y., and Han, C.* (2007) RNF151, a testis-specific RING finger protein, interacts with dysbindin, Archives of biochemistry and biophysics 465, 157-163.
  34. Shi, Y. Q., Wang, Q. Z., Liao, S. Y., Zhang, Y., Liu, Y. X., and Han, C. S.* (2006) In vitro propagation of spermatogonial stem cells from KM mice, Front Biosci 11, 2614-2622.
  35. Walke, D. W., Han, C., Shaw, J., Wann, E., Zambrowicz, B., and Sands, A. (2001) In vivo drug target discovery: identifying the best targets from the genome,Current opinion in biotechnology 12, 626-631.
  36. Han, C. S.*, Chen, Y., Ezashi, T., and Roberts, R. M. (2001) Antiviral activities of the soluble extracellular domains of type I interferon receptors, PNAS 98, 6138-6143.