研究员-- 干细胞与再生医学创新研究院

研究队伍

研究员

周兵

[研究员]

细胞微环境系统生物学研究组

联系方式 zhoubing@ioz.ac.cn +86-10-82619908 https://people.ucas.edu.cn/~bzhou

教育经历

2004年于湖南大学信息管理与信息系统系获得学士学位，2012年于中国科学院遗传与发育生物学研究所获得生物信息学博士学位，从事衰老系统生物学方向的研究。

工作经历

2012-2014年留所继续博士后研究工作，从事组蛋白去甲基化酶的表观遗传学精确调控机制的研究。2014-2018年在美国加州大学圣地亚哥分校进行博士后研究工作，从事RNA代谢调控网络与染色质高级结构的功能基因组方面的研究。

研究方向

实验室主要聚焦多细胞互作微环境中细胞的身份决定与维持、细胞间协作和组织、器官衰老与再生等科学问题，运用计算生物学与大规模高通量实验技术相结合的方法，从功能基因组学、表观遗传学、染色质高级结构以及单细胞生物学等多个生物学层面，系统性地阐释多细胞微环境的性质、功能与分子调控机制。

代表性发表论文

Bing Zhou, Xiao Li, Daji Luo, Do-Hwan Lim, Yu Zhou, and Xiang-Dong Fu. GRID-seq for comprehensive analysis of global RNA-chromatin interactions. Nature Protocols, 2019.
Peng Liu^, Shuaibin Zhang^, Bing Zhou^, Xi Luo, Xiaofeng Zhou, Bin Cai, Yinhua Jin, De Niu, Jinxing Lin, Xiaofeng Cao, and Jingbo Jin. The histone H3K4 Demethylase JMJ16 represses leaf senescence in Arabidopsis. The Plant Cell, 2019.
Xiao Li^, Bing Zhou^, Liang Chen, Lan-Tao Gou, Hairi Li, Xiang-Dong Fu. GRID-seq reveals the global RNA-chromatin interactome. Nature biotechnology, 2017.
Jinsong Qiu^, Bing Zhou^, Felicitas Thol, Yu Zhou, Liang Chen, Changwei Shao, Christopher DeBoever, Jiayi Hou, Hairi Li, Anuhar Chaturvedi, Arnold Ganser, Rafael Bejar, Dong-Er Zhang, Xiang-Dong Fu, Michael Heuser. Distinct splicing signatures affect converged pathways in myelodysplastic syndrome patients carrying mutations in different splicing regulators. RNA, 2016.
Xia Cui^, Falong Lu^, Qi Qiu^, Bing Zhou^, Lianfeng Gu, Shuaibin Zhang, Yanyuan Kang, Xiekui Cui, Xuan Ma, Qingqing Yao, Jinbiao Ma, Xiaoyu Zhang, Xiaofeng Cao. REF6 recognizes a specific DNA sequence to demethylate H3K27me3 and regulate organ boundary formation in Arabidopsis. Nature genetics, 2016.
Shuaibin Zhang^, Bing Zhou^, Yanyuan kang, Xia Cui, Ao Liu, Angelique Deleris, Maxim V. C. Greenberg, Xiekui Cui, Qi Qiu, Falong Lu, James A. Wohlschlegel, Steven E. Jacobsen and Xiaofeng Cao. C-terminal domains of histone demethylase JMJ14 interact with a pair of NAC transcription factors to mediate specific chromatin association. Cell Discovery, 2015.
Bing Zhou^, Liu Yang^, Shoufeng Li, Jialiang Huang, Haiyang Chen, Lei Hou, Jinbo Wang, Christopher D. Green, Zhen Yan, Xun Huang, Matt Kaeberlein, Li Zhu, Huasheng Xiao, Yong Liu, and Jing-Dong J. Han. Midlife gene expressions identify modulators of aging through dietary interventions. PNAS, 2012.
Hong Yu^, Shanshan Zhu^, Bing Zhou^, Huiling Xue, and Jing-Dong Jackie Han. Inferring causal relationships among different histone modifications and gene expression. Genome Research, 2008.