研究队伍

研究员

王雁玲

[研究员]

生殖病理学研究组

联系方式 wangyl@ioz.ac.cn +86-10-64807195 http://rpb.ioz.cas.cn/yjz/wangyanling/

教育经历

    1993年毕业于中国科学技术大学;1998年于中国科学院动物研究所获得生理学博士学位,师从庄临之研究员.

工作经历

    博士,研究员,博士生导师;中国科学院动物研究生殖病理研究组组长。

研究方向

    主要致力于研究胎盘发育和妊娠适应性调控的分子机理,并以此为切入点研究子痫前期和复发流产等重大妊娠疾病的发病机制。长期研究目标在于揭示人类胎盘发育和妊娠维持调控的分子机理,并发展重要妊娠疾病的预测和干预的综合策略。

代表性发表论文

  1. Luo R, Wang Y, Xu P, Cao G, Zhao Y, Shao X, Li YX, Chang C, Peng C, Wang YL*.Hypoxia-inducible miR-210 contributes to preeclampsia via targeting thrombospondin type I domain containing 7A. Sci Rep. 2016, 6:19588

  2. Li S, Wang Y, Cao B, Wu Y, Ji L, Li YX, Liu M, Zhao Y, Qiao J, Wang H, Wang H, Han C, Wang YL*.Maturation of GDF15 in human placental trophoblast cells depends on the interaction with matrix metalloproteinase-26 (MMP-26). J Clin Endo Metab, 2014, 99(11):E2777-87

  3. Luo R, Shao X, Xu P, Liu Y, Wang Y, Zhao Y, Liu M, Ji L, Li YX, Chang C, Qiao J, Peng C*, Wang YL* MicroRNA-210 contributes to preeclampsia by down-regulating KCMF1. Hypertension, 2014 64:839-847

  4. Xu P, Zhao Y, Liu M, Wang Y, Wang H, Li YX, Zhu X, Yao Y, Wang H, Qiao J, Ji L, Wang YL*. Variations of micrornas in human placentas and plasma from preeclamptic pregnancy. Hypertension, 2014, 63:1276-1284

  5. Burton GJ*, Sebire NJ, Myatt L, Tannetta D, Wang YL, Sadovsky Y, Staff AC, Redman CW (2014). Optimising sample collection for placental research. Placenta, 35(4):289-303

  6. Ji L, Brki? J, Liu M, Fu G, Peng C*, Wang YL*. Placental trophoblast cell differentiation: physiological regulation and pathological relevance to preeclampsia. Mol Asp Med, 2013,34:981-1023

  7. Yu L, Li D, Liao Q, Yang H, Cao B, Fu G, Ye G, Bai Y, Wang H, Cui N, Liu M, Li YX, Peng C, Wang YL*. High levels of ActivinA detected in preeclamptic placenta induce trophoblast cell apoptosis by promoting Nodal signaling. J Clin Endo Metab, 2012, 97: E1370–E1379

  8. Yang Y, Wang Y, Zeng X, Ma XJ, Zhao Y, Qiao J, Cao B,Li YX, Ji L, Wang YL*. Self-control of HGF regulation on human trophoblast cell invasion via enhancing c-Met receptor shedding by ADAM10 and ADAM17. J Clin Endo Metab, 2012, 97: E1390–E1401

  9. Bai Y, Yang W, Yang H, Liao Q, Ye G, Fu G, Ji L, Xu P, Wang H, Li YX, Peng C, Wang YL*. Downregulated miR-195 detected in preeclamptic placenta affects trophoblast cell invasion via modulating ActRIIA expression. PLoS ONE, 2012, 2012;7(6):e38875

  10. Gao WL, Liu M, Li D, Yang H, Liao Q, Yang Y, Bai Y, Li YX, Peng C, Wang YL*. The imprinted H19 gene regulates human placental trophoblast cell proliferation via encoding miR-675 that targets Nodal Modulator 1 (NOMO1). RNA Biol, 2012, 9:1002-1010

  11. Gao WL, Li D, Xiao Z, Liao QP, Yang HX, Li Y, Ji L,Wang YL*. Detection of global DNA methylation and paternally imprinted H19 gene methylation in preeclamptic placentas. Hyp Res, 2011, 34(5):655-61.