研究队伍

研究员

刘长梅

[研究员]

干细胞与神经发育疾病研究组

联系方式 liuchm@ioz.ac.cn +86-10-82619690 http://rpb.ioz.cas.cn/yjz/liuchangmei/

教育经历

    2004年博士毕业于中国协和医科大学生化与分子生物学系。

工作经历

    2004年到2008年在中国科学院微生物研究所工作，先后任助理研究员和副研究员。2008年起分别在美国新墨西哥大学和约翰霍普金斯大学做博士后研究。2015年加入中国科学院动物研究所，主要从事神经发生、神经再生、神经退行性疾病与神经发育疾病相关研究。

研究方向

    利用多种干细胞与神经发育、神经损伤及神经退行性疾病模型，研究神经干细胞自我更新和分化潜能的分子机理, 探索神经损伤与再生修复机制，揭示相关神经疾病发生发展的致病机理，建立干细胞介导的神经系统相关疾病的治疗。研究组主要研究方向：（1）染色质动态修饰调控神经发育；（2）神经损伤修复调控机制；（3）人源功能性神经前体细胞的定向分化；(4) 干细胞治疗的转化研究。

代表性发表论文

  1. Ma JJ, Ju X, Xu RJ, Wang WH, Luo ZP, Liu CM, Zhou FQ, Saijilafu. Telomerase Reverse Transcriptase and p53 Regulate Mammalian Peripheral Nervous System and CNS Axon Regeneration Downstream of c-Myc. J Neurosci. 2019 Nov 13;39(46):9107-9118.

  2. Xi F, Xu RJ, Xu JH, Ma JJ, Wang WH, Liu CM, Yang HL, Meng B, Saijilafu. Calcium/calmodulin-dependent protein kinase II regulates mammalian axon growth by affecting F-actin length in growth cone. J Cell Physiol. 2019 Dec;234(12):23053-23065.

  3. Zhang SF, Gao J, Liu CM#. The Role of Non-Coding RNAs in Neurodevelopmental Disorders. Front Genet. 2019 Nov 20;10:1033.

  4. Yan HL, Sun XW, Wang ZM, Liu PP, Mi TW, Liu C, Wang YY, He XC, Du HZ, Liu CM#, Teng ZQ#. MiR-137 Deficiency Causes Anxiety-Like Behaviors in Mice. Front Mol Neurosci. 2019 Oct 30; 12:260.

  5. Xu YJ*, Liu PP*, Ng SC, Teng ZQ, Liu CM#. Regulatory Networks between Polycomb Complexes and Non-coding RNAs in Central Nervous System. J Mol Cell Biol. 2019 Jul 10. pii: mjz058 (*Co-first author).

  6. Liu C*, Dai SK*, Sun Z, Wang Z, Liu PP, Du HZ, Yu S, Liu CM#, Teng ZQ#. GA-binding protein GABPβ1 is required for the proliferation of neural stem/progenitor cells. Stem Cell Res. 2019 Aug; 39:101501(*Co-first author).

  7. Liu PP*, Xu YJ*, Dai SK, Du HZ, Wang YY, Li XG, Teng ZQ, Liu CM#. Polycomb Protein EED Regulates Neuronal Differentiation through Targeting SOX11 in Hippocampal Dentate Gyrus. Stem Cell Reports. 2019 Jul 9;13(1):115-131(*Co-first author).

  8. Cheng Y*, Wang ZM*, Tan W*, Wang X*, Li Y, Bai B, Li Y, Zhang SF, Yan HL, Chen ZL, Liu CM, Mi TW, Xia S, et al. Partial loss of psychiatric risk gene Mir137 in mice causes repetitive behavior and impairs sociability and learning via increased Pde10a. Nat Neurosci. 2018 Dec;21(12):1689-1703(*Co-first author).

  9. Duan RS*, Tang GB*, Du HZ*, Hu YW, Liu PP, Xu YJ, Zeng YQ, Zhang SF, Wang RY, Teng ZQ, Liu CM#. Polycomb protein family member CBX7 regulates intrinsic axon growth and regeneration. Cell Death and Differentiation. 2018 Sep;25(9):1598-1611(*Co-first author).

  10. Liu PP*, Xu YJ*, Teng ZQ, Liu CM#. Polycomb Repressive Complex 2: Emerging Roles in the Central Nervous System. Neuroscientist. 2018 Jun;24(3):208-220(*Co-first author).

  11. Tang GB*, Zeng YQ*, Liu PP*, Mi TW, Zhang SF, Dai SK, Tang QY, Yang L, Xu YJ, Yan HL, Du HZ, Teng ZQ, Zhou FQ, Liu CM#. The histone h3k27 demethylase utx regulates synaptic plasticity and cognitive behaviors in mice. Front Mol Neurosci, 2017, 10:267(*Co-first author).

  12. Liu PP, Tang GB, Xu YJ, Zeng YQ, Zhang SF, Du HZ, Teng ZQ#, Liu CM#. MiR-203 Interplays with polycomb repressive complexes to regulate the proliferation of neural stem/progenitor cells. Stem Cell Reports. 2017,9(1):190-202.

  13. Li P, Teng ZQ, Liu CM#. Extrinsic and intrinsic regulation of axon regeneration by micrornas after spinal cord injury. Neural Plasticity, 2016:1279051.

  14. Jiang JJ*, Liu CM*, Zhang BY, Wang XW, Zhang M, Saijilafu, Zhang SR, Hall P, Hu YW, Zhou FQ. MicroRNA-26a supports mammalian axon regeneration in vivo by suppressing GSK3β expression. Cell Death and Disease. 2015, 6: e1865 (*Co-first author).

  15. Liu CM*, Wang RY*, Saijilafu, Jiao ZX, Zhang BY, Zhou FQ. MicroRNA-138 and SIRT1 form a mutual negative feedback loop to regulate mammalian axon regeneration. Genes Dev. 2013, 27(13):1473-83(*Co-first author).

  16. Liu CM*, Teng ZQ*, Santistevan NJ, Szulwach KE, Guo W, Jin P, Zhao X. Epigenetic regulation of miR-184 by MBD1 governs neural stem cell proliferation and differentiation. Cell Stem Cell. 2010, 6(5):433-44 (*Co-first author).

  17. Saijilafu, Hur EM, Liu CM, Jiao ZX, Xu WL, and Zhou F-Q. PI3K-GSK3 pathway regulates mammalian axon regeneration by induction of Smad1. Nature Communications, 2013, 4:2690.

  18. Guo W, Zhang Li, Christopher DM, Teng ZQ, Fausett SR, Liu CM, George OL, Klingensmith J, Jin P, Zhao X. RNA binding protein FXR2 regulates proliferation and differentiation of adult hippocampal neural stem cells by repressing Noggin expression. Neuron, 2011, 70:924-938.

  19. Liu CM, Teng ZQ, McQuate AL, Jobe EM, Christ CC, Hoyningen-Huene SJ, Reyes MD, Polich ED, Xing Y, Li Y, Guo W, Zhao X. An Epigenetic Feedback Regulatory Loop Involving MicroRNA-195 and MBD1 Governs Neural Stem Cell Differentiation PLoS One. 2013,8(1): e51436.

  20. Cong HL, Sun LQ, Liu C, Tien P. bition of atrogin-1/MAFbx expression by adenovirus-delivered small hairpin RNAs attenuates muscle atrophy in fasting mice. Hum Gene Ther. 2011 Mar;22(3):313-24.

  21. Li X, Barkho BZ, Luo Y, Smrt RD, Santistevan NJ, Liu C, Kuwabara T, Gage FH, Zhao X. Epigenetic regulation of the stem cell mitogen Fgf-2 by Mbd1 in adult neural stem/progenitor cells. J Biol Chem. 2008, 283 (41):27644-77652.

  22. Luo Y, Shan G, Guo W, Smrt RD, Johnson EB, Li X, Pfeiffer RL, Szulwach KE, Duan R, Barkho BZ, Li W, Liu C, Jin P, Zhao X. Fragile x mental retardation protein regulates proliferation and differentiation of adult neural stem/progenitor cells. PLoS Genet. 2010, 8;6(4): e1000898.

  23. Liu CM, Zhao XY. MicroRNAs in adult and embryonic neurogenesis. Neuromolecular Med. 2009,11 (3):141-152.

  24. Liu CM, Yang Z, Liu CW, Wang R, Tien P, Dale R, Sun LQ. Myostatin antisense RNA-mediated muscle growth in normal and cancer cachexia mice. Gene Ther. 2008, 15 (3):155-160.

  25. Gong H, Liu CM, Liu DP, Liang CC. The role of small RNAs in human diseases: potential troublemaker and therapeutic tools. Med Res Rev. 2005, 25(3):361-381.

  26. Ke XS, Liu CM, Liu DP, Liang CC. MicroRNAs: key participants in gene regulatory networks. Curr Opin Chem Biol. 2003 7(4):516-523.

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