研究员-- 干细胞与再生医学创新研究院

研究队伍

研究员

郭靖涛

[研究员]

生殖细胞与受精研究组

联系方式 jingtao.guo@ioz.ac.cn

教育经历

2013年7月毕业于北京大学生命科学学院，获理学学士学位。后赴美国犹他大学求学，师从著名科学家Bradley Cairns教授（美国科学与艺术学院院士，HHMI研究员），并于2018年6月获癌症科学博士学位。

工作经历

研究方向

（1）研究精原干细胞的自我复制、分化的分子机理

（2）建立适合模拟人类精原干细胞的体内（in vivo）和体外（in vitro）模型

（3）研究男性不育的分子机理，并以此为基础寻找治疗男性不育的新方法

代表性发表论文

（#共同第一作者, *通讯作者）

Mahyari E#, Guo J#,*, Lima AC, Vigh-Conrad KA, Nie X, Nagirnaja L, Rockweiler N, Carrell DT, Hotaling JM, Aston KI, Conrad DF*. Comparative Single-Cell Analysis of Biopsies Clarifies Pathogenic Mechanisms in Klinefelter Syndrome. American Journal of Human Genetics. (2021) 108(10):1924-1945.
Guo J*, Sosa E, Chitiashvili T, Nie X, Rojas EJ, Oliver E, DonorConnect, Hotaling JM, Stukenborg J, Clark AT*, Cairns BR*. Single-Cell Analysis of the Developing Human Testis Reveals Somatic Niche Cell Specification and Fetal Germline Stem Cell Establishment. Cell Stem Cell. (2021) 28(4):764-778.
Murphy PJ#, Guo J#, Jenkins TG, James ER, Hoidal JR, Huecksteadt J, Hotaling JM, Carrell DT, Cairns BR, Aston KI. NRF2 Loss Recapitulates Heritable Impacts of Paternal Cigarette Smoke Exposure. PLOS Genetics (2020) 16(6):e1008756.
Pan F#, Xiao X#, Guo J#, Song Y#, Li H#, Patel DP, Spivak AM, Alukal JP, Zhang X, Xiong C, Li PS, Hotaling JM. No Evidence of SARS-CoV-2 in Semen of Males Recovering from COVID-19. Fertility and Sterility (2020) 113(6):1135-1139.
Guo J, Nie X, Giebler M, Mlcochova H, Wang Y, Grow EJ, DonorConnect, Kim R, Tharmaligham M, Matilionyte G, Mitchell RT, Lindskog L, Carrell DT, Goriely A, Hotaling JM, Cairns BR. The Dynamic Transcriptional Cell Atlas of Testis Development During Human Puberty. Cell Stem Cell (2020) 26(2): 262-276.
Guo J, Grow EJ, Mlcochova H, Maher GJ, Lindskog C, Nie X, Guo Y, Takei Y, Yun J, Cai L, Kim R, Carrell DT, Goriely A, Hotaling JM, Cairns BR. The Adult Human Testis Transcriptional Cell Atlas. Cell Research (2018) 28: 1141-1157.
Guo J, Grow EJ, Yi C, Mlcochova H, Maher GJ, Lindskog C, Murphy PJ, Wike CL, Carrell DT, Goriely A, Hotaling JM, Cairns BR. Chromatin and Single-Cell RNA-seq Profiling Reveal Dynamic Signaling and Metabolic Transitions during Human Spermatogonial Stem Cell Development. Cell Stem Cell (2017) 21(4): 533-546.