研究队伍

研究员

焦建伟

[研究员]

神经干细胞增殖与分化研究组

联系方式 jwjiao@ioz.ac.cn +86-10-64806335 http://rpb.ioz.cas.cn/yjz/jiaojianwei/

教育经历

    2002年在北京大学生命科学学院获得博士学位。

工作经历

    2002年到2007年在美国哈佛医学院从事博士后研究，2008年被提升为Instructor。2009年到2011年在中科院神经所任研究员。2011年8月加入中科院动物所任研究员。

研究方向

    主要研究方向: 1.探讨神经干细胞增殖机制，发现新的调控神经干细胞自我更新和增殖的关键因子，探索脑大小及脑沟回形成的关键分子及机制，研究脑发育异常的调控因素及机制；2.研究神经元及神经胶质细胞分化的调控机理，解析内源因子和外源信号通路如何协同调控神经干细胞-神经元及神经胶质细胞转化过程，研究关键基因与信号通路间动态变化的协同调控所发生的细胞命运转换、细胞形态以及细胞迁移之间的关系，揭示神经细胞分化和迁移的调控机制；3.研究神经元转分化，为移植细胞治疗脑疾病治疗提供可能的细胞来源。

代表性发表论文

  1. Li Y, Li Z, Yang M, Wang F, Zhang Y, Li R, Li Q, Gong Y, Wang B, Fan B, Wang C, Chen L, Li H, Ong J, Teng Z, Jin L*, Wang YL*, Du P*, Jiao J*. Decoding the temporal and regional specification of microglia in the developing human brain. Cell Stem Cell. 2022 doi: 10.1016/j.stem.2022.02.004

  2. Wang W, Su L, Ji F, Zhang D, Wang Y, Zhao J, Jiao RD, Zhang M, Huang E, Jiang H, Zhang J, Jiao J*. The human FOXM1 homolog promotes basal progenitor cell proliferation and cortical folding in mouse. EMBO Rep. 2022 23:e53602.

  3. Ji F*, Wang W, Feng C, Gao F, Jiao J*. Brain-specific Wt1 Deletion Leads to Depressive-like Behaviors in Mice via the Recruitment of Tet2 to Modulate Epo Expression. Mol Psychiatry. 2021 26:4221-4233.

  4. Ma H, Su L, Xia W, Wang W, Tan G, Jiao J. MacroH2A1.2 deficiency leads to neural stem cell differentiation defects and autism-like behaviors. EMBO Rep. 2021 22:e52150.

  5. Zhang D, Liu C, Li H, Jiao J*. Deficiency of STING-signaling in embryonic cerebral cortex leads to neurogenic abnormalities and autistic-like behaviors. Adv Sci. 2020 7:2002117

  6. Zhang M, Zhao J, Lv Y, Wang W, Feng C, Zou W, Su L, Jiao J*. Histone variants and histone modifications in neurogenesis. Trends Cell Biol. 2020 30:869-880.

  7. Feng C, Zhao J, Ji F, Su L, Chen Y, Jiao J*. TCF20 dysfunction leads to cortical neurogenesis defects and autistic-like behaviors in mice. EMBO Rep. 2020 21:e49239.

  8. Liang Q, Su L, Zhang D, Jiao J*. CD93 negatively regulates astrogenesis in response to MMRN2 through the transcriptional repressor ZFP503 in the developing brain. Proc Natl Acad Sci USA. 2020 117:9413-9422.

  9. Su L, Lei X, Ma H, Feng C, Jiang J, Jiao J*. PRDM16 orchestrates angiogenesis via neural differentiation in the developing brain. Cell Death Differ. 2020 doi: 10.1038/s41418-020-0504-5.

  10. Li Y, Jiao J*. Deficiency of TRPM2 leads to embryonic neurogenesis defects in hyperthermia. Science Advances. 2020 6:eaay6350.

  11. Li Z, Li Y, Jiao J*. Neural progenitor cells mediated by H2A.Z.2 regulate microglial development via Cxcl14 in the embryonic brain. Proc Natl Acad Sci USA. 2019 116:24122-24132.

  12. Xia W, Su L, Jiao J*. Cold-induced protein RBM3 orchestrates neurogenesis via modulating Yap mRNA stability during cold stress. J Cell Biol. 2018 217:3464-3479.

  13. Su L, Xia W, Shen T, Liang Q, Wang W, Li H, Jiao J*. H2A.Z.1 crosstalk with H3K56-acetylation controls gliogenesis through the transcription of folate receptor. Nucleic Acids Res. 2018 46:8817-8831.

  14. Lei X, Jiao J*. UTX affects neural stem cell proliferation and differentiation through PTEN signaling. Stem Cell Reports. 2018 10:1193-1207.

  15. Qiao H, Li Y, Feng C, Duo S, Ji F, Jiao J*. Nap1l1 controls embryonic neural progenitor cell proliferation and differentiation in the developing brain. Cell Rep. 2018 22:2279-2293.

  16. Shen T, Ji F, Wang Y, Lei X, Zhang D, Jiao J*. Brain-specific deletion of histone variant H2A.z results in cortical neurogenesis defects and neurodevelopmental disorder. Nucleic Acids Res. 2018 46:2290-2307.

  17. Liang Q, Xia W, Li W, Jiao J*. RNF20 controls astrocytic differentiation through epigenetic regulation of STAT3 in the developing brain. Cell Death Differ. 2018 25:294-306.

  18. Li Y, Jiao J*. Histone chaperone HIRA regulates neural progenitor cell proliferation and neurogenesis via β-catenin. J Cell Biol. 2017 216:1975-1992.

  19. Xia W, Jiao J*. Histone variant H3.3 orchestrates neural stem cell differentiation in the developing brain. Cell Death Differ. 2017 24:1548-1563.

  20. Ji F, Shen T, Zou W, Jiao J*. UCP2 regulates embryonic neurogenesis via ROS-Mediated Yap alternation in the developing neocortex. Stem Cells. 2017 35:1479-1492.

  21. Yan L, Li Y, Shi Z, Lu X, Ma J, Hu B, Jiao J*, Wang H*. The zinc finger E-box-binding homeobox 1 (Zeb1) promotes the conversion of mouse fibroblasts into functional neurons. J Biol Chem. 2017 292:12959-12970.

  22. Zhang J, Chen S, Zhang D, Shi Z, Li H, Zhao T, Hu B, Zhou Q, Jiao J*. Tet3-Mediated DNA demethylation contributes to the direct conversion of fibroblast to functional neuron. Cell Rep. 2016 17:2326–2339.

  23. Wang S, Liang Q, Qiao H, Li H, Shen T, Ji F, Jiao J*. DISC1 regulates astrogenesis in the embryonic brain via modulation of RAS/MEK/ERK signaling through RASSF7. Development. 2016 143:2732-2740.

  24. Jiang H, Lv X, Lei X, Yang Y, Yang X, Jiao J*. Immune regulator MCPIP1 modulates TET expression during early neocortical development. Stem Cell Reports. 2016 7:439-453.

  25. Shi Z, Zhang J, Chen S, Li Y, Lei X, Qiao H, Zhu Q, Hu B, Zhou Q, Jiao J*. Conversion of Fibroblasts to Parvalbumin Neurons by One Transcription Factor, Ascl1, and the Chemical Compound Forskolin. J Biol Chem. 2016 291:13560-13570.

  26. Shen T, Ji F, Yuan Z, Jiao J*. CHD2 is required for embryonic neurogenesis in the developing cerebral cortex. Stem Cells. 2015 33:1794-1806.

  27. Xia W, Liu Y, Jiao J*. GRM7 regulates embryonic neurogenesis via CREB and YAP. Stem Cell Reports. 2015 4:795-810.

  28. Lv X, Jiang H, Liu Y, Lei X, Jiao J*. MicroRNA-15b promotes neurogenesis and inhibits neural progenitor proliferation by directly repressing TET3 during early neocortical development. EMBO Rep. 2014 15:1305-1314.

  29. .Wang S, Li B, Qiao H, Lv X, Liang Q, Shi Z, Xia W, Ji F, Jiao J*. Autophagy-related gene Atg5 is essential for astrocyte differentiation in the developing mouse cortex. EMBO Rep. 2014 15:1053-1061.

  30. Zhang J, Ji F, Liu Y, Lei X, Li H, Ji G, Yuan Z, Jiao J*. Ezh2 regulates adult hippocampal neurogenesis and memory. J Neurosci. 2014 34:5184-5199.

  31. Huang W, She L, Chang X, Yang R, Wang L, Ji H, Jiao J, Poo M. Protein kinase LKB1 regulates polarized dendriteformation of adult hippocampal newborn neurons. Proc Natl Acad Sci USA. 2014 111:469-474.

  32. Shi Z, Shen T, Liu Y, Huang Y, Jiao J*. Retinoic acid receptor gamma (Rarg) and nuclear receptor subfamily 5, group A, member 2 (Nr5a2) promote conversion of fibroblasts to functional neurons. J Biol Chem. 2014 289:6415-6428.

  33. Lv X, Jiang H, Li B, Liang Q, Wang S, Zhao Q, Jiao J*. The crucial role of Atg5 in cortical neurogenesis during early brain development. Sci Rep. 2014 4:6010.

  34. Meng F, Chen S, Miao Q, Zhou K, Lao Q, Zhang X, Guo W, Jiao J*. Induction of fibroblasts to neurons through adenoviral gene delivery. Cell Res. 2012 22:436-440.

  35. Jiao J, Feldheim DA, Chen DF. Ephrins as negative regulators of adult neurogenesis in diverse regions of the central nervous system. Proc Natl Acad Sci USA. 2008 105: 8778-8783.

  36. Jiao J, Chen DF. Induction of neurogenesis in non-conventional neurogenic regions of the adult CNS by niche astrocyte-produced signals, Stem Cells. 2008 26:1221-1230.

  37. Jiao J, Huang X, Feit-Leithman RA, Neve RL, Snider W, Dartt DA, Chen DF. Bcl-2 enhances Ca2+ signaling to support the intrinsic regenerative capacity of CNS axons. EMBO J. 2005 24:1068-1078.

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