联系方式 huangsq@ioz.ac.cn +86-10-64807768 http://rpb.ioz.cas.cn/yjz/huangshiqiang/


    2008年于普林斯顿大学 Princeton University 获得分子生物学理学学位(最优等荣誉)。2013年于哈佛医学院 Harvard Medical School 获得生物医学博士学位。


    2013年至2017年担任新加坡基因组研究所 Genome Institute of Singapore 研究组组长。后加入中科院动物所。




  1. Le, M. T., Teh, C.*, Shyh-Chang, N.*, Xie, H., Zhou, B., Korzh, V., Lodish, H. F., and Lim, B. (2009). MicroRNA-125b is a novel negative regulator of p53. Genes Dev. 23, 862–76.

  2. Zhu, H., Shah, S., Shyh-Chang, N., Shinoda, G., Einhorn, W. S., Viswanathan, S. R., Takeuchi, A., Grasemann, C., Rinn, J. L., Lopez, M. F., Hirschhorn, J. N., Palmert, M. R., and Daley, G. Q. (2010). Lin28a transgenic mice manifest size and puberty phenotypes identified in human genetic association studies. Nature Genetics 42, 626-30.

  3. Zhu, H.*, Shyh-Chang, N.*, Segre, A. V., Shinoda, G., Shah, S. P., Einhorn, W. S., Takeuchi, A., Engreitz, J. M., Hagan, J. P., Kharas, M. G., Urbach, A., Thornton, J. E., Triboulet, R., Gregory, R. I., DIAGRAM Consortium, MAGIC Investigators, Altshuler, D., and Daley GQ. (2011). The Lin28/let-7 axis regulates glucose metabolism. Cell 147, 81-94.

  4. Le, M. T.*, Shyh-Chang, N.*, Khaw, S. L., Chin, L., Teh, C., Tay, J., O'Day, E., Korzh, V., Yang, H., Lal, A., Lieberman, J., Lodish, H. F., and Lim, B. (2011). Conserved regulation of p53 network dosage by microRNA-125b occurs through evolving miRNA-target gene pairs. PLoS Genetics 7, e1002242.

  5. Shyh-Chang, N., Zheng, Y., Locasale, J. W. and Cantley, L. C. (2011). Human pluripotent stem cells decouple respiration from energy production. EMBO Journal 30, 4851-4852.

  6. Zhang, W. C., Shyh-Chang, N., Yang, H., Rai, A., Umashankar, S., Ma, S., Soh, B. S., Sun, L. L., Tai, B. C., Nga, M. E., Bhakoo, K. K., Jayapal, S. R., Nichane, M., Yu, Q., Ahmed, D. A., Tan, C., Sing, W. P., Tam, J., Thirugananam, A., Noghabi, M. S., Pang, Y. H., Ang, H. S., Mitchell, W., Robson, P., Kaldis, P., Soo, R. A., Swarup, S., Lim, E. H., and Lim, B. (2012). Glycine decarboxylase activity drives non-small cell lung cancer tumor-initiating cells and tumorigenesis. Cell 148, 259-72.

  7. Shinoda, G., Shyh-Chang, N., de Soysa, T. Y., Zhu, H., Seligson, M. T., Shah, S. P., Abo-Sido, N., Yabuuchi, A., Hagan, J. P., Gregory, R. I., Asara, J. M., Cantley, L. C., Moss, E. G., and Daley, G. Q. (2013). Fetal deficiency of Lin28 programs life-long aberrations in growth and glucose metabolism. Stem Cells. doi: 10.1002/stem.1423.

  8. Shyh-Chang, N., Locasale, J. W., Lyssiotis, C. A., Zheng, Y., Teo, R. Y., Ratanasirintrawoot, S., Zhang, J., Onder, T., Unternaehrer, J. J., Zhu, H., Asara, J. M., Daley, G. Q., and Cantley, L. C. (2013). Influence of threonine metabolism on S-adenosylmethionine and histone methylation. Science 339, 222-226.

  9. Shyh-Chang, N., Daley, G. Q., and Cantley, L. C. (2013). Stem cell metabolism during tissue development and aging. Development 12, 2535-47.

  10. Shyh-Chang, N. and Daley, G. Q. (2013). Lin28: Primal regulator of growth and metabolism in stem cells. Cell Stem Cell 12, 395-406.

  11. Shyh-Chang, N., Zhu, H., de Soysa, T. Y., Shinoda, G., Seligson, M. T., Tsanov, K. T., Nguyen L., Asara, J. M., Cantley, L. C., and Daley, G. Q. (2013). Lin28 enhances tissue repair by reprogramming cellular metabolism. Cell 155, 778-92.

  12. Shyh-Chang, N. and Daley, G. Q. (2015). Metabolic switches linked to pluripotency and embryonic stem cell differentiation. Cell Metabolism 21, 349-50

  13. Khaw, S. L., Min-Wen, C., Koh, C. G., Lim, B., and Shyh-Chang, N. (2015). Oocyte factors suppress mitochondrial polynucleotide phosphorylase to remodel the metabolome and enhance reprogramming. Cell Reports 12(7), 1080-8.

  14. Wu, L.*, Nguyen L. H.*, Zhou, K., de Soysa, T. Y., Li, L., Miller, J. B., Tian, J., Locker, J., Zhang, S., Shinoda, G., Seligson, M. T.,  Zeitels, L. R., Acharya, A., Wang, S. C., Mendell, J. T., He, X., Nishino, J., Morrison, S. J., Siegwart, D. J., Daley, G. Q., Shyh-Chang, N., Zhu, H. (2015).  Precise let-7 expression levels balance organ regeneration against tumor suppression. eLife 10.7554

  15. Liu TM, Lee EH, Lim B, Shyh-Chang, N. (2015). Balancing Stem Cell Self-renewal and Differentiation with PLZF. Stem Cells doi: 10.1002/stem.2270.

  16. Jun-Hao ET, Gupta RR, Shyh-Chang, N. (2016). Lin28 and let-7 in the metabolic physiology of aging. Trends Endocrinol. Metab. S1043-2760(15)00251-9. doi: 10.1016/j.tem.2015.12.006.

  17. Min-Wen JC, Jun-Hao ET, Shyh-Chang, N. (2016). Stem cell mitochondria during aging. Seminars in Cell and Developmental Biology. doi:10.1016/j.semcdb.2016.02.005.

  18. Tan, J.L., Fogley, R.D., Flynn, R.A., Ablain, J., Yang, S., Saint-André, V., Fan, Z.P., Do, B.T., Laga, A.C., Fujinaga, K., Santoriello, C., Greer, C.B., Kim, Y.J., Clohessy, J.G., Bothmer, A., Pandell, N., Avagyan, S., Brogie, J.E., van Rooijen, E., Hagedorn, E.J., Shyh-Chang, N., White, R.M., Price, D.H., Pandolfi, P.P., Peterlin, B.M., Zhou, Y., Kim, T.H., Asara, J.M., Chang, H.Y., Young, R.A., Zon, L.I. (2016). Stress from Nucleotide Depletion Activates the Transcriptional Regulator HEXIM1 to Suppress Melanoma. Molecular Cell. 62(1), 34-46.

  19. Fukawa, T., Yan-Jiang, B.C., Min-Wen, J.C., Jun-Hao, E.T., Huang, D., Qian, C.N., Ong, P., Li, Z., Mohan, R.E., Wang, R.R., Kanayama, H., Lai, J.H., Chua, C., Ong, H.S., Tan, K.K., Ho, Y.S., Tan, I.B., Teh, B.T., Shyh-Chang, N. (2016).Excessive fatty acid oxidation induces muscle atrophy in cancer cachexia. Nature Medicine. 22(6), 666-71.

  20. Loh KM, Chen A, Koh PW, Deng TZ, Sinha R, Tsai JM, Barkal AA, Shen KY, Jain R, Morganti RM, Shyh-Chang N, Fernhoff NB, George BM, Wernig G, Salomon REA, Chen Z, Vogel H, Epstein JA, Kundaje A, Talbot WS, Beachy PA, Ang LT, Weissman IL. (2016). Mapping the Pairwise Choices Leading from Pluripotency to Human Bone, Heart, and Other Mesoderm Cell Types. Cell. 166, 451-467.

  21. Lee HJ, Jedrychowski MP, Vinayagam A, Wu N, Shyh-Chang N, Hu Y, Min-Wen C, Moore JK, Asara JM, Lyssiotis CA, Perrimon N, Gygi SP, Cantley LC, Kirschner MW. (2017). Proteomic and metabolomic characterization of a mammalian cellular transition from quiescence to proliferation. Cell Rep. 20(3), 721-736.

  22. Liu TM, Shyh-Chang N. (2017). SIRT2 and glycolytic enzyme acetylation in pluripotent stem cells. Nat Cell Biol. 19(5), 412-414.

  23. Andriani Y#, Chua JM#, Chua BY, Phang IY, Shyh-Chang N*, Tan WS*. (2017). Polyurethane acrylates as effective substrates for sustained in vitro culture of human myotubes. Acta Biomater. 57, 115-126.

  24. Shyh-Chang N and Huck-Hui Ng. (2017). The Metabolic Programming of Stem Cells. Genes Dev. 31(4), 336-346.

  25. Min-Wen JC, Yan-Jiang BC, Mishra S, Dai X, Magae J, Shyh-Chang N, Kumar AP, Sethi G. (2017). Molecular Targets of Ascochlorin and Its Derivatives for Cancer Therapy. Adv Protein Chem Struct Biol. 108, 199-225.

  26. Shyh-Chang N. (2017). Metabolic Changes During Cancer Cachexia Pathogenesis. Adv Exp Med Biol. 1026, 233-249.

  27. Usman WM, Pham TC, Kwok YY, Vu LT, Ma V, Peng B, Chan YS, Wei L, Chin SM, Azad A, He AB, Leung AYH, Yang M, Shyh-Chang N, Cho WC, Shi J, Le MTN. (2018). Efficient RNA drug delivery using red blood cell extracellular vesicles. Nat Commun. 9, 2359.

  28. Zhang X, Liu Z, Liu X, Wang S, Zhang Y, He X, Sun S, Ma S, Shyh-Chang N, Liu F, Wang Q, Wang X, Liu L, Zhang W, Song M, Liu GH, Qu J. (2019). Telomere-dependent and telomere-independent roles of RAP1 in regulating human stem cell homeostasis. Protein Cell. doi: 10.1007/s13238-019-0610-7

  29. Chua MJ, Yildirim ED, Tan JE, Chua YB, Low SC, Ding SLS, Li CW, Jiang Z, Teh BT, Yu K, Shyh-Chang N. (2019). Assessment of different strategies for scalable production and proliferation of human myoblasts. Cell Prolif. e12602. doi: 10.1111/cpr.12602.

  30. Li CW*, Yu K#, Shyh-Chang N#, Li GX, Jiang LJ, Yu SL, Xu LY, Liu RJ, Guo ZJ, Xie HY, Li RR, Ying J, Li K, Li DJ. (2019). Circulating factors associated with sarcopenia during ageing and after intensive lifestyle intervention. J Cachexia Sarcopenia Muscle. doi: 10.1002/jcsm.12417.

  31. Jiang Z, Guang L, Li L, Shyh-Chang N#. (2019). Putting stem cells on a low-fat diet switches their pluripotent state. Cell Stem Cell, doi: 10.1016/j.stem.2019.06.002.

  32. Xu YJ, Liu PP, Ng SC, Teng ZQ, Liu CM. (2019). Regulatory Networks between Polycomb Complexes and Non-coding RNAs in Central Nervous System. J Mol Cell Biol, doi: 10.1093/jmcb/mjz058.

  33. Liu T, Shyh-Chang N#. (2019). Oncofetal SALL4-driven tumorigenesis is highly dependent on oxidative phosphorylation, revealing therapeutic opportunities. Gastroenterology,doi: 10.1053/j.gastro.2019.09.044.

  34. Xu C, Ooi WF, Qamra A, Tan J, Chua BY, Ho SWT, Das K, Adam Isa ZF, Li Z, Yao X, Yan T, Xing M, Huang KK, Lin JS, Nandi T, Tay ST, Lee MH, Tan ALK, Ong X, Ashktorab H, Smoot D, Li S, Ng SC, Teh BT, Tan P. (2020). HNF4α pathway mapping identifies wild-type IDH1 as a targetable metabolic node in gastric cancer. Gut, doi: 10.1136/gutjnl-2018-318025.

  35. Liu TM, Yildirim ED, Li P, Fang HT, Denslin V, Kumar V, Loh YH, Lee EH, Cool SM, Teh BT, Hui JH, Lim B, Shyh-Chang N#. (2020). Ascorbate and iron are required for the specification and long-term self-renewal of human skeletal mesenchymal stromal cells. Stem Cell Reports, doi: 10.1016/j.stemcr.2020.01.002.

  36. Wu J, Song D, Li Z, Guo B, Xiao Y, Liu W, Liang L, Feng C, Gao T, Chen Y, Li Y, Wang Z, Wen J, Yang S, Liu P, Wang L, Wang Y, Peng L, Stacey GN, Hu Z, Feng G, Li W, Huo Y, Jin R, Shyh-Chang N, Zhou Q, Wang L, Hu B, Dai H, Hao J. Immunity-and-matrix-regulatory cells derived from human embryonic stem cells safely and effectively treat mouse lung injury and fibrosis. Cell Res. 2020 Sep;30(9):794-809.

  37. Yao Z, Chen Y, Cao W, Shyh-Chang N#. Chromatin-modifying drugs and metabolites in cell fate control. Cell Prolif. 2020 Nov;53(11):e12898.

  38. Xiaoxiao Wang, Yunlong Xiang, Yang Yu, Ran Wang, Yu Zhang, Qianhua Xu, Hao Sun, Zhen-Ao Zhao, Xiangxiang Jiang , Xiaoqing Wang, Xukun Lu, Dandan Qin, Yujun Quan, Jiaqi Zhang, Ng Shyh-Chang, Hongmei Wang, Naihe Jing, Wei Xie, Lei Li. Formative pluripotent stem cells show features of epiblast cells poised for gastrulation. Cell Res. 2021 Feb 19. doi: 10.1038/s41422-021-00477-x.

  39. Chun-Wei Li, Kang Yu#, Ng Shyh-Chang#, Guo-Xun Li, Song-Lin Yu , Hui-Jun Liu, Bo Yang, Zi-Yao Li, Yong-Jie Zhao, Long-Yu Xu, Jing Xu, Ling-Juan Jiang, Rong-Ji Liu, Xin-Yuan Zhang, Shao-Fei Li, Xiao-Wei Zhang, Hai-Yan Xie, Kang Li, Yi-Xiang Zhan, Min Cui, Hang-Bo Tao, Yao Li, Gao-Shan Liu, Ke-Min Ni, Dong-Jing Li. Sterol metabolism and protein metabolism are differentially correlated with sarcopenia in Asian men and women. Cell Prolif. 2021 Feb 20;e12989. doi: 10.1111/cpr.12989

  40. Ng Shyh-Chang# and Lei Li#. Stabilizing formative pluripotent states with germ cell competency. Cell Stem Cell. 2021 Mar; doi: 10.1016/j.stem.2021.02.021.

  41. Fan T, Wang S, Jiang Z, Ji S, Cao W, Liu W, Ji Y, Li Y, Shyh-Chang N#, Gu Q#. Controllable assembly of skeletal muscle-like bundles through 3D bioprinting. Biofabrication. 2021 Dec 1;14(1). doi: 10.1088/1758-5090/ac3aca.

  42. Li CW, Yu K#, Shyh-Chang N#, Jiang Z, Liu T, Ma S, Luo L, Guang L, Liang K, Ma W, Miao H, Cao W, Liu R, Jiang LJ, Yu SL, Li C, Liu HJ, Xu LY, Liu RJ, Zhang XY, Liu GS. Pathogenesis of sarcopenia and the relationship with fat mass. J Cachexia Sarcopenia Muscle. 2022 Feb 2. doi: 10.1002/jcsm.12901.

  43. Liu Z, Li W, Geng L, Sun L, Wang Q, Yu Y, Yan P, Liang C, Ren J, Song M, Zhao Q, Lei J, Cai Y, Li J, Yan K, Wu Z, Chu Q, Li J, Wang S, Li C, Han JJ, Hernandez-Benitez R, Shyh-Chang N, Belmonte JCI, Zhang W, Qu J, Liu GH. Cross-species metabolomic analysis identifies uridine as a potent regeneration promoting factor. Cell Discov. 2022 Feb 1;8(1):6. doi: 10.1038/s41421-021-00361-3.

  44. Chew EGY, Lim TC, Leong MF, Liu X, Sia YY, Leong ST, Yan-Jiang BC, Stoecklin C, Borhan R, Heilmann-Heimbach S, Nothen MM, Viasnoff V, Shyh-Chang N, Wan ACA, Philpott MP, Hillmer AM. Observations that suggest a contribution of altered dermal papilla mitochondrial function to androgenetic alopecia. Exp Dermatol. 2022 Feb 4. doi: 10.1111/exd.14536.

  45. Ma S, Shyh-Chang N#. The Metabaging Cycle. Cell Prolif. 2022 Mar;55(3):e13197. doi: 10.1111/cpr.13197. Epub 2022 Feb 2.