研究队伍

研究员

赵勇

[研究员]

移植生物学研究组

联系方式 zhaoy@ioz.ac.cn +86-10-64807302 http://www.biomembrane.ioz.cas.cn/yjz/zhaoyong/pi/

教育经历

    1993年7月在白求恩医科大学获生物学博士。

工作经历

　　1993年8月－1995年3月 日本东京三菱化成生命科学研究所，特别研究员；

　　1995年3月－2000年5月 哈佛大学/麻省总医院移植生物学研究中心，博士后；

　　2000年5月起至2003年8月 美国内布拉斯加大学医学院，外科兼病理与微生物科助理教授；

　　2003年8月－ 中科院动物所研究员，博士导师


研究方向

    主要从事同种/异种移植免疫排斥反应及T细胞免疫耐受的诱导及其分子机制、抑制性T细胞的诱导与应用、胸腺发育分化的分子调节、巨噬细胞生物学等免疫学领域的研究。

代表性发表论文

  1. 赵勇主编. 2003. 异种移植免疫学. 中国医药科技出版社. 中国: 北京.
  2. 赵勇主编. 2005. 移植免疫耐受. 中国医药科技出版社. 中国: 北京.
  3. Sun L, Sun C, Liang Z, Li H, Chen L, Luo H, Zhang H, Ding P, Sun X, Qin Z* and Zhao Y* FSP1+ fibroblast subpopulation is essential for the maintenance and regeneration of thymic medullary zone. Journal of Immunology 2014 (revision)
  4. Sun L, Zhang H, Luo H, Liang Z, Du J, Wu L, Zhang L, Lu J, and Zhao Y* Acute allograft rejection significantly impairs host thymic medullary epithelial cell homeostasis via IL-17. American Journal of Transplantation 2014 (revision)
  5. Wang Z, Zhou S, Sun C, Lei T, Peng J, Li W, Ding P, Lu J, and Zhao Y* IFN-γ inhibits non-opsonized phagocytosis of macrophages via an mTORC1-c/EBPβ pathway. Journal of Innate Immunology 2014 (revision).
  6. Zhu L, Yang T, Li L, Sun L, Hou Y, Hu X, Zhang L, Tian H, Zhao Q, Peng J, Zhang H, Wang R, Yang Z, Zhang L, and Zhao Y* TSC1 controls macrophage polarization to prevent inflammatory disorder. Nature Communications 2014 (accepted)
  7. Hou Y, Lin H, Zhu L, Liu Z, Hu F, Shi J, Yang T, Shi X, Guo H, Tan X, Zhang L, Wang Q*, Li Z*, and Zhao Y* IFN-γ inhibits TLR ligands-induced protease HTRA1 expression in rheumatoid arthritis. Journal of Immunology 2014 (online).
  8. Deng X, Zhang F, Wang L, Rui W, Long F, Zhao Y*, Chen D, Ding W* Airborne fine particulate matter induces multiple cell death pathways in human lung epithelial cells. Apoptosis 2014 19(7):1099-112.
  9. Chen, H, Yang, T, Zhu, L., Zhao Y* Cellular Metabolism on T-Cell Development and Function. International Review of Immunology. 2014 (on line)
  10. Shen X, Du J, Guan W, and Zhao Y* The balance of intestinal Foxp3+ regulatory T cells and Th17 cells and its biological significance. Expert Review of Clinical Immunology 2014 10(3): 353-362.
  11. Xiao W, Meng G, Zhao Y, Chang Z, Li T, Sun C, Li Z, Zhao Y, Luo M, Zheng X* Human secreted protein SI-CLP aggravates the inflammation of rheumatoid arthritis and is a potential macrophage inflammatory regulator Arthritis & Rheumatism 2014 66(5): 1141-1152.
  12. Sun L, Li H, Luo H, and Zhao Y* Thymic epithelial cell development and its dysfunction in human diseases. BioMed Research International 2014: 206929
  13. Luo H, Wang C, Feng M, Zhao Y*. Microgravity inhibits resting T cell immunity in an exposure time-dependent manner. International Journal of Medical Sciences 2014 11(1): 87-96.
  14. Wang C, Luo H, Zhu L, Yang F, Chu Z, Tian H, Feng M, Shang P*, Zhao Y * Microgravity inhibition of lipopolysaccharide-induced TNF-α expression in macrophage cells. Inflammation Research 2014 63(1): 91-98.
  15. Sun B, Hu X, Liu G, Ma B, Xu Y, Yang T, Shi J, Yang F, Li H, Zhang L*, and Zhao Y* Phosphatase Wip1 negatively regulates neutrophil antimicrobial immunity.  Journal of Immunology 2014 192(3): 1184-1195.
  16. Sun L, Li H, Luo H, Zhang L, Hu X, Yang T, Sun C, Chen H, Zhang L and Zhao Y*. Phosphatase Wip1 is essential for the maturation and homeostasis of medullary thymic epithelial cells in mice Journal of Immunology 2013 191(6): 3210-3220.
  17. Chen H, Zhang LJ, Zhang HB, Li L, Xiao Y, Sun LN, Li H, Corley D, Liu G, Yang ZZ*, and Zhao Y* TSC1/2 complex negatively regulates thymic CD4+CD25+Foxp3+Treg development in mice. FASEB J 2013 27(10): 3979-3990.
  18. Hou Y, Lin H, Duan K, Zhu L, Liu Z, Hu F, Shi J, Rao E, Yang T, Shi X, Yin Z, Zhu M, Zhang L, Godley F. B., Wang Q*, Li Z*, and Zhao Y* LPS increases the incidence of collagen-induced arthritis in mice through induction of protease HTRA1 expression  Arthritis & Rheumatism 2013  65(11): 2835-2846.
  19. Liu G, Hu X, Sun B, Shi J, Zhang L*, and Zhao Y.* Phosphatase Wip1 negatively regulates neutrophil development through p38 MAPK-STAT1. Blood 2013 121(3): 519-529. 
  20. Sun LN, Li HR, Luo HY, and Zhao Y.* Thymic epithelial cell development and differentiation: Cellular and molecular regulations. Protein Cell 2013 4(5): 342-355.
  21. Wu T,  Sun C, Chen Z, Zhen Y, Peng J, Qi Z., Yang X., and Zhao Y* Smad3-deficient CD11b+Gr1+ myeloid-derived suppressor cells prevent allograft rejection via the nitric oxide pathway Journal of Immunology 2012 189(10): 4989-5000.
  22. Ge Q. and Zhao Y. Evolution of thymus organogenesis Dev Comp Immunol 2013 39(1-2): 85-90.
  23. Hu X, Liu G, Hou Y, Shi J, Zhu L, Jin D, Peng J, and Zhao Y*  Induction of recipient M2 macrophages by allogeneic donor regulatory CD4+CD25+ T cells in mice Cell Mol Immunol 2012 9(6): 464-472.
  24. Sun C., Jiang Y., Sun L., Shang H.*, and Zhao Y.* The characteristics of Th1/Th2 cytokine receptors on monocytes in untreated patients of long term nonprogressor or chronic HIV infection. Current Molecule Medicine. 2012 12(8): 1028-1039.
  25. Wu, T., Zhang, L., Xu, K., Sun, C., Lei, T., Peng, J., Liu, G., Wang, R., Zhao Y*, Immunosuppressive drugs on inducing Ag-specific CD4+CD25+Foxp3+ Treg cells during immune response in vivo. Transplant Immunology, 2012, 27(1): 30-38
  26. Huang, L., Wang, Z. B. Jiang, Z. Z. Hu, M. W. Lin, F., Zhang, Q. H., Luo, Y. B., Hou, Y., Zhao, Y., Fan, H. Y., Schatten, H. Specific disruption of Tsc1 in ovarian granulosa cells promotes ovulation and causes progressive accumulation of corpora lutea. PLoS One 2012, 8(1): e54052.
  27. Sun, Q. Y.Liu, X., Ma, B., Malik, A. B., Tang, H., Yang, T., Sun, B., Wang, G., Minshall, R. D., Li, Y., Zhao, Y., Ye, R. D., and  Xu, J.* Bidirectional regulation of neutrophil migration by mitogen-activated protein kinases Nature Immunology 2012, 13(5): 457-464.
  28. Y. Zhang L, Li L, Xiao Y, Rao E, Miao Z, Chen H, Sun L, Li H, Zhang H and Zhao Y* TSC1/2 pathway critically regulates peripheral na？ve CD8+ T cell survival and homeostasis in mice PLoS One 2012, 7(2): e30592.
  29. Jin, D., Duan, K., Zhang, L., Peng, J., and Zhao, Y.* The effects of leflunomide on CD4+CD25+Foxp3+ T regulatory cells in mice receiving allogeneic bone marrow transplantation. Inflammation Research 2012, 61(1): 53-60.
  30. Zeng C, Shi X, Zhang B, Liu H, Zhang L, Ding W, and Zhao Y* The imbalance of Th17/Th1/Tregs in patients with type 2 diabetes: Relationship with metabolic factors and complications. J Molecular Medicine 2012, 90(2): 175-186.
  31. Zhen, Y., Sun, L., Liu, H., Duan, K., Zeng, C., Zhang, L., Jin, D., Peng, J., Ding, W.*, and Zhao, Y.* Alterations of peripheral CD4+CD25+Foxp3+ T regulatory cells in mice with STZ-induced diabetes. Cell Mol Immunol 2012, 9(1): 75-85.
  32. Sun C, Sun L, Ma H, Peng J, Zhen Y, Duan K, Liu G, Ding W*  and Zhao Y.* The phenotype and functional alterations of macrophages in mice with hyperglycemia for long term J of Cell Physiology 2012, 227(4): 1670-1679.
  33. Duan K, Zhang B, Zhang W, Zhao Y, Qu Y, Sun C, and Zhao Y* Efficient peripheral construction of functional human regulatory CD4+CD25highFoxp3+ T cells in NOD/SCID mice grafted with fetal human thymus/liver tissues and CD34+ cells Transpl Immunol 2011, 25(4): 173-179.
  34. Liu G, Duan K, Ma H, Niu Z, Peng J, and Zhao Y*  An instructive role of donor macrophages in mixed chimeras in the induction of CD4+Foxp3+ Treg cells. Immunology and Cell Biology 2011, 89(8): 827-835.
  35. Lai L*, Cui C, Jin J, Hao Z, Zheng Q, Ying M, Boyd R, and Zhao Y Mouse embryonic stem cell-derived thymic epithelial cell progenitors enhance T-cell reconstitution after allogeneic bone marrow transplantation Blood 2011; 118(12): 3410-3418
  36. Javeed A, Hou Y, Duan K, Zhang B, Shen H, Cao Y, Zhao Y*. Aspirin significantly decreases the nonopsonic phagocytosis and immunogenicity of macrophages in mice. Inflammation Research, 2011, 60(4): 389-398.
  37. Liu G, Ma H, Qiu L, Li L, Cao Y, Ma J, Zhao Y*. Phenotypic and functional switch of macrophages induced by regulatory CD4(+)CD25(+) T cells in mice. Immunology and Cell Biology. 2011, 89(1):130-42.
  38. Zhu S, Peigneur S, Gao B, Luo L, Jin D, Zhao Y, Tytgat. J  Molecular Diversity and Functional Evolution of Scorpion Potassium Channel Toxins. Molecular & Cellular Proteomics  2011;10(2):M110.002832
  39. Liu G, Zhang L and Zhao Y*. Modulation of immune responses through direct activation of Toll-like receptors to T cells. Clinical and Experimental Immunology, 2010, 160: 168-175.
  40. Qu Y, Zhang B, Liu S, Zhang A, Wu T, Zhao Y*. 2-Gy whole-body irradiation significantly alters the balance of CD4+CD25-T effector cells and CD4(+)CD25(+)Foxp3(+)T regulatory cells in mice. Cellular & Molecular Immunology. 2010, 7(6): 419-427.
  41. Sun Y, Zhu Z, Langnas AN, Grant WJ, Botha JF, Zhao Y, Sudan DL, Mercer DF. Plasma nitrite and nitrate levels as a noninvasive marker of pathology after human small bowel transplantation. Transplantation. 2010, 89(3): 307-311.
  42. Sun L, Guo J, Brown R, Amagai T, Zhao Y, Su DM. Declining expression of a single epithelial cell-autonomous gene accelerates age-related thymic involution. Aging Cell 2010, 9(3): 347-357.
  43. Zhao Y* and Li X*. Cross-immune tolerance: conception and its potential significance on transplantation tolerance. Cellular & Molecular Immunology 2010, 7(1): 20-25.
  44. Liang H, Yang L, Ma T and Zhao Y*. Functional expression of cystic fibrosis transmembrane conductance regulation in mouse chondrocytes. Clinical and Experimental Pharmacology & Physiology. 2010, 37: 506-508.
  45. Qu YY, Zhang AJ, Zhang BJ, Wang JJ and Zhao Y.*. Gamma-Ray Resistance of Regulatory CD4+CD25+Foxp3+ T Cells in mice. Radiation Research 2010, 173(2): 148-157.
  46. Jiang P, Rao EY, Meng N, Zhao Y, Wang JJ: MicroRNA-17-92 significantly enhances radioresistance in human mantle cell lymphoma cells. Radiation Oncology 2010, 5:100.
  47. Zhang Y, Wang J, Liu F, You Z, Yang R, Zhao Y: EGFR inhibitor C225 increases the radiosensitivity of human lung squamous cancer cells. Cancer Cell International 2010, 10:39.
  48. You ZY, Zhao Y, Liu F, Zhang YD, Wang JJ: The radiosensitization effects of Endostar on human lung squamous cancer cells H-520. Cancer Cell International 2010, 10:17.

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