[研究员]
2011年于瑞典卡罗琳斯卡医学院获医学硕士学位,2015年于美国圣路易斯华盛顿大学获理学博士学位。
2016年起于美国斯坦福大学从事心血管方面的博士后研究,2018年初加入中国科学院动物研究所,成立线粒体与疾病研究组。
心脏衰老及相关疾病的机制与干预
Yang C, Du H, Liu S, Xu P, Wang Y, Zhou Y, Yuan H, Li Y, Shen J, Yuan X, Li M, He C, Zhang J, Xiao Y, Bi J, Hou Y, Zang J, Gao Z, Song M*. Targeting Age-related LINE-1 Activation Alleviates Cardiac Aging. Nature Aging (Cover Story). 2026 Feb;6(2):414-429.
Li Y, Wang Y, Zhang H, Xu P, Yuan X, Yuan H, Yang C, Zhou Y, Shen J, Du H, Gao Z, Zang J, Liang S*, Qu J*, Song M*. PARKIN overexpression confers cardioprotection via suppressing the mtDNA-cGAS-STING axis in myocardial ischemia/reperfusion injury. Basic Research in Cardiology. 2026 Mar 13. doi: 10.1007/s00395-026-01169-6. Online ahead of print.
Wang Y, Li Y, Zhou Y, Zhang H, Zang J, Yang C, Gao Z, Hou Y, Song M*. Nynrin Enhances Cardiac Function by Inhibiting Mitochondrial Permeability Transition Pore Opening Upon Myocardial Ischemia/Reperfusion Injury. Journal of Molecular and Cellular Cardiology. 2025 Dec;209:93-103.
Du H, You X, Zhang J, Liu S, Zhou Y, Wang Y, Yang C, Meng Y, Liu X, Zhang H, Li Y, Shen J, Yuan H, Xu P, He C, Xiao Y, Gao Z, Zang J, Wei T*, Song M*. CAR Macrophages Engineered In Vivo for Attenuating Myocardial Ischemia-Reperfusion Injury. Circulation Research (Featured Article). 2025 Aug 29;137(6):846-859.
Xiao Y, Zhang H, Liu X, Xu P, Du H, Wang J, Shen J, Li Y, Wang Y, He C, Feng H, Liu J, Zhou Y, Liu S, Gao Z, Zang J, Bi J, Tang TS, Gu Q, Wei T, Wang J, Song M*. Medium From Human iPSC-Derived Primitive Macrophages Promotes Adult Cardiomyocyte Proliferation and Cardiac Regeneration. Nature Communications. 2025 Mar 27;16(1):3012.
Du H, Liu X, Shen J, Yuan H, Zhang H, Xi G, Li Y, Wang Y, Zhang J, Yang C, Xu P, Wang J, Wang F, Liu S, Zhou Y, Gu Q, Lu J, Wei T, Gao Z, Zang J, Wang J*, Song M*. Flavonifractor Plautii or Its Metabolite Desaminotyrosine as Prophylactic Agents for Alleviating Myocardial Ischemia/Reperfusion Injury. Advanced Science (Frontispiece Article). 2025 Mar 16:e2417827.
Geng L, Ping J, Wu R, Yan H, Zhang H, Zhuang Y, Ning T, Wang J, Liang C, Zhang J, Chu Q, Zhang J, Wen Y, Jing Y, Sun S, Qiao Q, Zhao Q, Ji Q, Ma S, Cai Y, Zheng Y, Zou Z, Diao Z, Li M, Zhang H, Hu J, Fu L, Kang W, Bai R, Zhao H, Zhang S, Ding Y, Lei J, Wang W, Ji Y, Gou B, Sun G, Yin J, Yan P, Li H, Wang Z, Ma S, Liu Z, Shan H, Wang Q, Cao T, Yang S, Wang C, Yang P, Fan Y, Ye Y, Hu J, Jiang M, Wang Y, Liu K, Li Y, Li Y, Li J, Ci W, Jin ZB, Fu X, Zhang X, Zhao G, Izpisua Belmonte JC, Wang S*, Song M*, Zhang W*, Qu J*, Liu GH*. Systematic Profiling Reveals Betaine as an Exercise Mimetic for Geroprotection. Cell. 2025 Jun 25:S0092-8674(25)00635-X.
Xiao Y, Xu P, Bi J, Song M*. Human iPSC-Derived Self-Assembled Cardiac Organoids for Evaluating Drug Developmental Cardiotoxicity. Life Medicine. 2025;4(4):lnaf018.
Wang J, Du H, Xie W, Bi J, Zhang H, Liu X, Wang Y, Zhang S, Lei A, He C, Yuan H, Zhang J, Li Y, Xu P, Liu S, Zhou Y, Shen J, Wu J, Cai Y, Yang C, Li Z, Liang Y, Zhao Y, Zhang J*, Song M*. CAR-Macrophage Therapy Alleviates Myocardial Ischemia-Reperfusion Injury. Circulation Research (Cover Story). 2024 Oct 28.
Wang J, Zhang H, Yuan H, Chen S, Yu Y, Zhang X, Gao Z, Du H, Li W, Wang Y, Xia P, Wang J*, Song M*. Prophylactic Supplementation With Lactobacillus reuteri or Its Metabolite GABA Protects Against Acute Ischemic Cardiac Injury. Advanced Science (Frontispiece Article). 2024 Mar 15:e2307233.
Zhang H, Wang J, Shen J, Chen S, Yuan H, Zhang X, Liu X, Yu Y, Li X, Gao Z, Wang Y, Wang J*, Song M*. Prophylactic Supplementation With Bifidobacterium infantis or Its Metabolite Inosine Attenuates Cardiac Ischemia/Reperfusion Injury. iMeta. 2024 Jul 2;3(4):e220.
Xia B, Shen J, Zhang H, Chen S, Zhang X, Song M*, Wang J*. The Alternative Splicing Landscape of Infarcted Mouse Heart Identifies Isoform Level Therapeutic Targets. Scientific Data. 2024 Oct 18;11(1):1154.
Chu Q, Liu F, He Y, Jiang X, Cai Y, Wu Z, Yan K, Geng L, Zhang Y, Feng H, Zhou K, Wang S, Zhang W, Liu GH*, Ma S*, Qu J*, Song M*. mTORC2/RICTOR Exerts Differential Levels of Metabolic Control in Human Embryonic, Mesenchymal and Neural Stem Cells. Protein Cell. 2022 Sep;13(9):676-682.
Gou B, Chu X, Xiao Y, Liu P, Zhang H, Gao Z, Song M*. Single-Cell Analysis Reveals Transcriptomic Reprogramming in Aging Cardiovascular Endothelial Cells. Frontiers in Cardiovascular Medicine. 2022 May 9;9:900978.
Shen J, Liu GH*, Song M*. Potential Approaches for Intervening Aging. National Science Open. 2022;1(2):20220021.
Ma S, Sun S, Li J, Fan Y, Qu J, Sun L, Wang S, Zhang Y, Yang S, Liu Z, Wu Z, Zhang S, Wang Q, Zheng A, Duo S, Yu Y, Belmonte JCI, Chan P, Zhou Q, Song M*, Zhang W*, Liu GH*. Single-cell Transcriptomic Atlas of Primate Cardiopulmonary Aging. Cell Research. 2021 Apr;31(4):415-432.
Zhang J, Liu GH*, Qu J*, Song M*. Treating Osteoarthritis Via Gene Therapy With Rejuvenation Factors. Gene Therapy. 2020 Aug;27(7-8):309-311.
Wang Y, Li Y, He C, Gou B, Song M*. Mitochondrial Regulation of Cardiac Aging. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 2019 Jul 1;1865(7):1853-1864.
Song M, Franco A, Fleischer JA, Zhang L, Dorn GW 2nd. Abrogating Mitochondrial Dynamics in Mouse Hearts Accelerates Mitochondrial Senescence. Cell Metabolism. 2017 Dec 5;26(6):872-883.e5.
Gong G#, Song M#, Csordas G, Kelly DP, Matkovich SJ, Dorn GW 2nd. Parkin-Mediated Mitophagy Directs Perinatal Cardiac Metabolic Maturation in Mice. Science. 2015 Dec 4;350(6265):aad2459.
Song M, Gong G, Burelle Y, Gustafsson ÅB, Kitsis RN, Matkovich SJ, Dorn GW 2nd. Interdependence of Parkin-Mediated Mitophagy and Mitochondrial Fission in Adult Mouse Hearts. Circulation Research. 2015 Jul 31;117(4):346-51.
Song M#, Matkovich SJ#, Zhang Y, Hammer DJ, Dorn GW 2nd. Combined Cardiomyocyte PKCδ and PKCε Gene Deletion Uncovers Their Central Role in Restraining Developmental and Reactive Heart Growth. Science Signaling. 2015 Apr 21;8(373):ra39.
Song M, Dorn GW 2nd. Mitoconfusion: Noncanonical Functioning of Dynamism Factors in Static Mitochondria of the Heart. Cell Metabolism. 2015 Feb 3;21(2):195-205.
Song M, Mihara K, Chen Y, Scorrano L, Dorn GW 2nd. Mitochondrial Fission and Fusion Factors Reciprocally Orchestrate Mitophagic Culling in Mouse Hearts and Cultured Fibroblasts. Cell Metabolism. 2015 Feb 3;21(2):273-286.
Song M, Chen Y, Gong G, Murphy E, Rabinovitch PS, Dorn GW 2nd. Super-Suppression of Mitochondrial Reactive Oxygen Species Signaling Impairs Compensatory Autophagy in Primary Mitophagic Cardiomyopathy. Circulation Research. 2014 Jul 18;115(3):348-53.