研究队伍

研究员

刘垒

[研究员]

细胞器稳态与疾病研究组

联系方式 liulei@ioz.ac.cn 010-64807321

教育经历

工作经历

研究方向

    线粒体及其他细胞器稳态调控与疾病。

代表性发表论文

  1. Wu H*, Wei H, Zhang D, Sehgal SA, Zhang D, Wang X, Qin Y, Liu L*, Chen Q*. Defective mitochondrial ISCs biogenesis switches on IRP1 to fine tune selective mitophagy. Redox Biol. 2020 Sep; 36:101661. (Co-corresponding author)

  2. Liu L, Liao X, Wu H, Li Y, Zhu Y, Chen Q*. Mitophagy and its contribution to metabolic and aging associated disorders. Antioxidants & Redox Signaling(invited review) 2020 Apr 20;32(12):906-927.  

  3. Wu H, Wang Y, Li W, Chen H, Du L, Liu D, Wang X, Xu T, Liu L*, Chen Q*. Deficiency of mitophagy receptor FUNDC1 impairs mitochondrial quality and aggravates dietary-induced obesity and metabolic syndrome. Autophagy2019 Mar 22:1-17 (Co-corresponding author)  

  4. Li Y, Xue Y, Xu X, Wang G, Liu Y, Wu H, Li W, Wang Y, Chen Z, Zhang W, Zhu Y, Ji W, Xu T, Liu L*, Chen Q* A mitochondrial FUNDC1/HSC70 interaction organizes the proteostatic stress response at the risk of cell morbidity. EMBO Journal 2019 Feb 1 38(3).

  5. Liu D, Wu H, Wang C, Li Y, Tian H, Siraj S, Sehgal SA, Wang X, Wang J, Shang Y, Jiang Z, Liu L*, Chen Q*. STING directly activates autophagy to tune the innate immune response. Cell Death and Differentiation2019 Sep;26(9):1735-1749.(Co-corresponding author)  

  6. Chen M, Chen Z, Wang Y, Tan Z, Zhu C, Li Y, Han Z, Chen L, Gao R, Liu L*, Chen Q*. Mitophagy receptor FUNDC1 regulates mitochondrial dynamics and mitophagy. Autophagy 2016 2(4):689-702 (Co-corresponding author; Highlighted by both EMBO Journal and by Faculty 1000 )

  7. Wu H, Xue D, Chen G, Han Z, Huang L, Zhu C, Wang X, Jin H, Wang J, Zhu Y, Liu L*, Chen Q*.The Bcl-xL and PGAM5 axis defines hypoxia-induced receptor-mediated mitophagy. Autophagy 2014 10:1712-25 (Co-corresponding author)

  8. Liu L, Sakakibara K, ChenQ*, Okamoto K*. Receptor-mediated mitophagy in yeast and mammalian systems. Cell Research, 2014 24(7):787-95.

  9. Liu L, Feng D, Chen G, Chen M, Zheng Q, Song P, Ma Q, Zhu C, Wang R, Qi W, Huang L, Xue P, Li B, Wang X, Jin H, Wang J, Yang F, Liu P, Zhu Y, Sui S, Chen Q*. Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells. Nature Cell Biology, 2012 14(2)177-85 (Landmark paper for mitophagy, Highlighted by Nature Chinaand by Faculty 1000).