研究员-- 干细胞与再生医学创新研究院

研究队伍

研究员

吕赫喆

[研究员]

细胞异质性与命运决定研究组

联系方式 Hezhe@ioz.ac.cn +86-10-6480 7150

教育经历

2011年于北京师范大学获得细胞生物学博士学位。

工作经历

毕业后于美国宾夕法尼亚大学、加拿大Lunenfeld-Tanenbaum研究所从事肿瘤异质性方面的博士后研究。2020年7月加入中国科学院动物研究所成立细胞异质性与命运决定研究组。

研究方向

实验室主要聚焦细胞异质性在疾病发生、发展中的作用，结合细胞生物学和生物信息学等手段，研究（1）探寻罕见耐药肿瘤细胞并设计靶点药物；（2）研究细胞发生致癌基因突变后的命运轨迹；（3）研究T细胞异质性，筛选刺激T细胞向肿瘤侵袭的小分子药物。

代表性发表论文

Hezhe Lu, Shujing Liu, Gao Zhang, Bin Wu, Yueyao Zhu, Dennie T. Frederick, Yi Hu, Wenqun Zhong, Sergio Randell, Norah Sadek, Wei Zhang, Gang Chen, Chaoran Cheng, Jingwen Zeng, Lawrence Wu, Jie Zhang, Xiaoming Liu, Wei Xu, Clemens Krepler, Katrin Sproesser, Min Xiao, Benchun Miao, Jianglan Liu, Claire D. Song, Jephrey Y. Liu, Giorgos C. Karakousis, Lynn M. Schuchter, Yiling Lu, Gordon Mills, Yusheng Cong, Jonathan Chernoff, Jun Guo, Genevieve M. Boland, Ryan J. Sullivan, Zhi Wei, Jeffrey Field, Ravi K. Amaravadi, Keith T. Flaherty, Meenhard Herlyn*, Xiaowei Xu*, Wei Guo* PAK signalling drives acquired drug resistance to MAPK inhibitors in BRAF-mutant melanomas. Nature (2017) 550(7674):133-136.
Hezhe Lu, Shujing Liu, Gao Zhang, Lawrence N. Kwong, Yueyao Zhu, John P. Miller, Yi Hu, Wenqun Zhong, Jingwen Zeng, Lawrence Wu, Clemens Krepler, Katrin Sproesser, Min Xiao, Wei Xu, Giorgos C. Karakousis, Lynn M. Schuchter, Jeffery Field, Paul J. Zhang, Meenhard Herlyn, Xiaowei Xu*, Wei Guo* Oncogenica BRAF-induced invadopodia formation and melanoma invasion. Cell Reports. (2016) 15(9): 2012–2024.
Hezhe Lu, Jianglan Liu, Shujing Liu, Jingwen Zeng, Deqiang Ding, Russ P. Carstens, Yusheng Cong, Xiaowei Xu and Wei Guo* Exo70 isoform switching upon Epithelial-Mesenchymal transition mediates cancer cell invasion. Developmental Cell. (2013) 27(5): 560-573.
Hezhe Lu, Ellen Fan, Suozhu Sun, Xiaoxiao Ma, Xiaoyan Zhang, David M.K. Han, and Yu-Sheng Cong* Cyr61 Is Up-Regulated in Prostate Cancer and Associated With the p53 Gene Status. J Cell Biochem. (2009) 106 (4): 738-744.
Shujing Liu, Suresh M Kumar, Hezhe Lu, Aihua Liu, Ruifeng Yang, Anitha Pushparajan, Wei Guo and Xiaowei Xu* MicroRNA-9 up-regulates E-cadherin through inhibition of NF-κB1–Snail1 pathway in melanoma. Journal of Pathology. (2012) 226: 61–72.
Suresh M Kumar, Shujing Liu, Hezhe Lu, Hongtao Zhang, Paul J. Zhang, Phyllis A. Gimotty, Matthew Guerra, Wei Guo and Xiaowei Xu* Acquired cancer stem cell phenotypes through Oct4-mediated dedifferentiation. (2012) Oncogene. 31(47):4898-91.1
Claude C Warzecha, Peng Jiang, Karine Amirikian, Kimberly A Dittmar, Hezhe Lu, Shihao Shen, Wei Guo, Yi Xing and Russ P Carstens* An ESRP-regulated splicing programme is abrogated during the epithelial–mesenchymal transition. EMBO J. (2010) 29 (19):3286-3300.