研究员-- 干细胞与再生医学创新研究院

研究队伍

研究员

于乐谦

[研究员]

干细胞与发育体外模拟研究组

联系方式 leqianyu@ioz.ac.cn +86-10-64807235

教育经历

2017年博士毕业于日本国立京都大学（日本国费留学生），随后于美国得克萨斯大学西南医学中心从事博士后研究工作。

工作经历

2022年8月全职加入中国科学院动物研究所。

研究方向

主要从事多能干细胞（包括胚胎干细胞和诱导多能性干细胞）的基础研究和转化应用。研究领域主要包括：

1. 基于人类多能干细胞构建人类早期胚胎发育、器官形成及疾病模型

2. 结合多能干细胞与微流控芯片技术研究人类早期胚胎发育关键事件

3. 不同物种诱导多能性干细胞的构建与应用

代表性发表论文

Yu, L. #; Wei, Y. #; Duan, J. #; Schmitz, D. A.; Sakurai, M.; Wang, L.; Wang, K.; Zhao, S.; Hon, G. C.*; Wu, J.*, Blastocyst-like structures generated from human pluripotent stem cells, Nature, 2021 (# Co-frist authors)

该工作入选Science杂志评选“Sicence 2021年科学10大突破进展”
该工作入选我国两院院士评选“2021年中国/世界十大科技进展新闻”
该工作被Natrue杂志（Vol 591, Issue 7851）选为当期封面故事
当期Nature杂志评论该工作“First complete model of the human embryo”
Nature新闻评论该工作“Lab-grown structures mimic human embryo's earliest stage yet”
Science新闻评论该工作 “Researchers re-create key human embryo stage in lab”
该工作同时被世界范围600多家媒体机构报道，包括 Xinhua News, NPR News, US News, New York Times, NHK News, Asahi News, NBC News等

Liu, T. #; Li, J. #; Yu, L. #; Sun, H.; Li, J.; Dong, G.; Hu, Y.; Li, Y.; Shen, Y.; Wu, J.*; Gu, Y.*, Cross-species single-cell transcriptomic analysis reveals pre-gastrulation developmental differences among pigs, monkeys, and humans, Cell discovery, 2021 (# Co-frist authors)
Zheng, C. #; Hu, Y. #; Sakurai, M. #; Pinzon-Arteaga, C. A.; Li, J.; Wei, Y.; Okamura, D.; Ravaux, B.; Barlow, H. R.; Yu, L.; Sun, H.; Chen, E. H.; Gu, Y.; Wu, J.*, Cell competition constitutes a barrier for interspecies chimerism, Nature, 2021
Yu, L. #; Wei, Y. #; Sun, H. #; Mahdi, A. K.; Pinzon Arteaga, C. A.; Sakurai, M.; Schmitz, D. A.; Zheng, C.; Ballard, E. D.; Li, J.; Tanaka, N.; Kohara, A.; Okamura, D.; Mutto, A. A.; Gu, Y.; Ross, P. J.; Wu, J.*, Derivation of Intermediate Pluripotent Stem Cells Amenable to Primordial Germ Cell Specification, Cell Stem Cell, 2020 (# Co-frist authors)

Cell Stem Cell杂志评论该工作“Stabilizing Formative Pluripotent States with Germ Cell Competency”
ScienceDaily New评论该工作 “Development of new stem cell type may lead to advances in regenerative medicine”
GEN News评论该工作“New Stem Cell Derived from Mice, Horses, and Humans”

Vilarino, M.; Soto, D.A.; Bogliotti, Y. S.; Yu, L.; Zhang, Y.; Wang, C.; Paulson, E.; Zhong, C.; Jin, C.; Izpisua Belmonte, J. C.; Wu, J.; Ross, P .J.*, Derivation of sheep embryonic stem cells under optimized conditions. Reproduction, 2020
Li, J. #; Zhang, L. #; Yu, L.; Minami, I.; Miyagawa, S.; Horning, M.; Dong, J.; Qiao, J.; Qu, X.; Hua, Y.; Fujimoto, N.; Shiba, Y.; Zhao, Y.; Tang, F.; Chen, Y.; Sawa, Y.*; Tang, C.*; Liu, L.*, Circulating re-entrant waves promote maturation of hiPSC-derived cardiomyocytes in self-organized tissue ring, Communications biology, 2020
Yu, L. #; Li, J. #; Itsunari, M.; Qu, X.; Miyagawa, S.; Fujimoto, N.; Hasegawa, K.; Chen, Y.; Sawa, Y.; Kotera, H.; Liu, L.*, Clonal Isolation of Human Pluripotent Stem Cells on Nanofibrous Substrates Reveals an Advanced Subclone for Cardiomyocyte Differentiation. Advanced Healthcare Materials, 2019 (# Co-frist authors)

该工作被Advanced Healthcare Materials杂志选为当期封面故事

Li, R. #; Zhong, C. #; Yu, Y. #; Liu, H.; Sakurai, M.; Yu, L.; Min, Z.; Shi, L.; Wei, Y.; Takahashi, Y.; Liao, H.; Qiao, J.; Deng, H.; Nunez-Delicado, E.; Rodriguez Esteban, C.; Wu, J. *; Izpisua Belmonte, J. C.*; Generation of Blastocyst-like Structures from Mouse Embryonic and Adult Cell Cultures. Cell, 2019
Zhang, Y.; Li, T.; Preissl, S.; Amaral, M.L.; Grinstein, J.D.; Farah, E.N.; Destici, E.; Qiu, Y.; Hu, R. Lee, A.Y.; Chee, S.; Ma, K.; Ye, Z.; Zhu, Q.; Huang, H.; Fang, R.; Yu, L.; Izpisua Belmonte, J.C.; Wu, J.; Evans, S.M.; Chi, N.C.*; Ren B*. Transcriptionally active HERV-H retrotransposons demarcate topologically associating domains in human pluripotent stem cells. Nature Genetics, 2019
Xu, J.; Yu, L.; Guo, J.; Xiang, J.; Zheng, Z.; Gao, D.; Shi, B.; Hao, H.; Jiao, D.; Zhong, L.; Wang, Y.; Wu, J.*; Wei, H. *; Han, J*. Generation of pig induced pluripotent stem cells using an extended pluripotent stem cell culture system. Stem Cell Research & Therapy, 2019
Yu, L.; Li, J.; Hong, J.; Takashima, Y.; Fujimoto, N.; Nakajima, M.; Dong, X.; Dang, Y.; Yang, W.; Okita, K.; Luo, C.; Tang, F.; Chen, Y.; Tang, C.*; Kotera, H.*; Liu, L.*, Low Cell-Matrix Adhesion Reveals Two Novel Subtypes of Human Pluripotent Stem Cells. Stem Cell Reports, 2018
Li, J. #; Minami, I. #; Yu, L.; Shiozaki, M.; Shiba, Y.; Yajima, S.; Morone, N.; Fukushima, S.; Yoshioka, M.; Li, S.; Qiao, J.; Li, X.; Wang, L.; Kotera, H.; Miyagawa, S.; Nakatsuji, N.; Sawa, Y.; Chen, Y.; Liu, L., Human Pluripotent Stem Cell-Derived Cardiac Tissue-Like Constructs for Repairing of the Infarcted Myocardium. Stem Cell Reports, 2017
Li, J.; Zhang, F.; Yu, L.; Fujimoto, N.; Yoshioka, M.; Li, X.; Shi, J.; Kotera, H.; Liu, L.* and Chen, Y. * , Culture substrates made of elastomeric micro-tripod arrays for long-term expansion of human pluripotent stem cells, J. Mater. Chem. B, 2017
Li, X.#; Yu, L.#; Li, J.; Minami, I.; Nakajima, M.; Noda, Y.; Kotera, H.; Liu, L.*; Chen, Y.*, On chip purification of hiPSC-derived cardiomyocytes using a fishnet-like microstructure, Biofabrication, 2016. (# Co-frist authors)
Tang, Y.; Liu, L.; Li, J.; Yu, L.; Wang, L.; Shi, J.; Chen, Y.*, Induction and Differentiation of Human Induced Pluripotent Stem Cells into Functional Cardiomyocytes on a Compartmented Monolayer of Gelatin Nanofibers. Nanoscale, 2016
Li, J.; Minami, I.; Yu, L.; Tsuji, K.; Nakajima, M.; Qiao, J.; Suzuki, M.; Shimono, K.; Nakatsuji, N.; Kotera, H.; Liu, L.*; Chen, Y.*, Extracellular Recordings of Patterned Human Pluripotent Stem Cell-Derived Cardiomyocytes on Aligned Fibers. Stem cells international, 2016
Tang, Y.; Liu, L.; Li, J.; Yu, L.; Severino, F. P. U.; Wang, L.; Shi, J.; Tu, X.; Torre, V.; Chen, Y.*, Effective Motor Neuron Differentiation of Hipscs on a Patch Made of Crosslinked Monolayer Gelatin Nanofibers. Journal of Materials Chemistry B, 2016